General

Question 1

What stimulates release of renin?

Answer 1

Beta-1 agonists

Question 2

All BBs seen in reference to…

Answer 2

propanolol
(in terms of relative affinity, intrinsic sympathomimetic activity, blockade of a-receptors, lipid solubility, vasodilation abililty, pk parameters)

Question 3

propanolol

Answer 3

competitive
non-specific BB
prototype

Question 4

Important distinguishing characteristics b/w beta-blockers…

Answer 4

membrane stabilizing activity

intrinsic agonist (sympathomimetic) activity

lipid solubility

plasma half-life

vasodilation ability

blockade of a receptors

Question 5

First Generation BBs

Answer 5

classical non-selective

Nadolol
penbutolol
pindolol
propranolol
timolol

Question 6

Second Generation BBs

Answer 6

B1 selective blockers

Acebutolol
atenolol
bisoprolol
esmolol
metoprolol

Question 7

Third generation BBs

Answer 7

non-selective blockers w/ additional actions

carteolol
carvedilol
labetalol

Question 8

Third generation BBs (part 2)

Answer 8

Beta-1 selective blockers w/ additional actions

betaxolol
bebivolol

Question 9

Esmolol

Answer 9

Extremely short half-life (given IV, so hour-by-hour control)