Antagonists w/ extended actions Flashcards
Antagonists w/ extended actions
pharmacologic effects on other receptor systems in body over and above b-blocking
NO production
carteolol
Nebivolol
B2 receptor agonism
carteolol
a1 receptor antagonism
carvedilol
labetalol
Ca entry blockade
Carvedilol
betaxolol
antioxidant activity
carvedilol
carteolol
NO production
b2 receptor agonism
Nebivolol
NO production
Carvedilol
a1 receptor antagonism
Ca entry blockade
antioxidant activity
Labetalol
a1 receptro antagonism
betaxolol
Ca Entry blockade
a1 receptor antagonism and Ca entry blockade prevent…
reflexive vasoconstriction effect produced by BBs when begin to be used clinically
(b/c BP initially declines, so vasoconstriction=homostatic mechanism)
Ca blockade…
inhibits contraction
B2 agonist…
increases cAMP…
vasodilation
NO production…
increases cGMP…
vasodilation
