Intracellular Receptors

Question 1

what are examples of intracellular receptors?

Answer 1

steroid receptors

Question 2

what is an example of a steroid receptor?

Answer 2

-cortisol receptor (glucocorticoid)

Question 3

how does a glucocorticoid work?

Answer 3

• glucocorticoid is bound to a heat shock protein (HSP)
• the HSP dissociates from the glucocorticoid to allow cortisol to bind
• this forms a cortisol-GR dimer (2 cortisol-GR complexes bound together)
• the dimer is able to pass through the nucleus membrane and bonds to the glucocorticoid response element
• this increases gene transcription

Question 4

how does the thyroid hormone receptor work?

Answer 4

• T3 is delivered to the cell bound to a binding globulin
• T3 diffuses across the plasma membrane into the nucleus
• T3 binds to the thyroid hormone receptor
• increases gene transcription

Question 5

what do lipid soluble agonists bind to?

Answer 5

-to cystolic receptors that migrate to nucleus
or
-binds directly to nuclear receptors