Intracellular Bacteria

Question 1

facultative intracellular pathogens (name 4)

Answer 1

neisseria, enterics, mycobacter, bacilli, legionella

Question 2

facultative intracellular pathogens (definition)

Answer 2

can divide independently and on agar plates but enter host cells as part of their pathogenesis

Question 3

obligate intracellular parasites

Answer 3

rickettsial chlamydia

require host cell resources to multiply. grown in tissue cultures like viruses.

Question 4

infected macrophages

Answer 4

used by pathogens for transport around the body and evade humoral and surface-innate immunity (actin-based cell-cell spread)

Question 5

Type 3 secretion systems

Answer 5

enhances phagocytosis by target cell type or alter the endosome so that lysosomes fail to fuse to it

Question 6

tetracyclines

Answer 6

cross human cell membrane but are contraindicated in pregnancy

Question 7

Listeria monocytogenes

Answer 7

facultative intracellular bacterium. results in gastroenteritis from contaminated cold stored pre prepared foods.

uses actin based mobility to spread between cells. can cause meningitis

Question 8

Rickettsia rickettsiae

Answer 8

obligate intracellular bacterium. transmitted by ticks. infects endothelium of blood vessels causing leakage and Rocky Mountain Spotted Fever.

carries virulence factors for adhesion, cell entry, endosomal escape and actin based cell-cell spread.