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patho > Intracellular Accumulation > Flashcards

Intracellular Accumulation Flashcards

1
Q

IC Accumulation happens due to

A

Manifestation of metabolic dearrangement

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2
Q

Progressive accumulation means

A

Death

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3
Q

Inadequate removal of normal endogenous substance is due to

A

Packaging and transport

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4
Q

Fatty liver changes is an example of

A

Inadequate removal of normal endogenous

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5
Q

Accumulation of abnormal endogenous substance is due to

A

Folding, Packaging , Secretion , Transport

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6
Q

Antitrypsin and alzehimer are examples of

A

Accumulation of abnormal endogenous substance

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7
Q

When metabolism degrading enzyme is defected ;

A

Normal endogenous substance accumulation

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8
Q

(Glycogen storage disease) is relates to

A

Normal endogenous substance accumulation

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9
Q

Absence of degrading or transposing mechanisms relates to

A

Abnormal exogenous substance accumulation

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10
Q

Ketone bodies, phospholipid, cholesterol ester are all related to

A

Free f.a catabolism

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11
Q

Fat build up in an organ (usually your liver)

A

Steatosis

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12
Q

Causes of lipid accumulation (5)

A
  1. Toxins(alcohol)
  2. Protein malnutrition
  3. DM
  4. Obesity
  5. Anoxia
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13
Q

Increasing of lipid synthesis and decreasing of breakdown is related to

A

Alcohol

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14
Q

Inhibiting f.a oxidation

A

Hypoxia

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15
Q

Consequences of cholesterol accumulation can be

A
  1. Atherosclerosis
  2. Xanthomas
  3. Cholesterolosis
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16
Q

Accumulation in subcutaneous tissue is related to

A

Xanthomas

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17
Q

A patient that is feeling pain in gallbladder, and the doctor is mostly thinking of cholecystitis is related to

A

Cholesterolosis

18
Q

Rounded , eosinophilic , vacuoles, or aggregates relates to

A

Protiens

19
Q

Glomerulonephritis appears in which color and where

A

Appears as pink hyaline droplet, when protein is accumulated in renal tubule.

20
Q

Accumulation of Igs in plasma cells is called

A

Russell bodies (seen in plasmacytosis and chronic inflammation)

21
Q

Accumulation of cytoskeleton proteins is called

A

Alcoholic hyaline (Mallory body)

22
Q

Neurofillaments , keratin, desmids are all related to

A

Alcohol hyaline (mallory body)

23
Q

Alcohol hyaline (mallory body) is found in

A

Liver

24
Q

Neurofibrillary tangle is related to which type of accumulation

A

Protein accumulation

25
Q

Glycogen is accumulated due to

A

Lack of enzymes for metabolism

26
Q

Glycogen accumulation is seen is two major places

A
  1. Glycogen storage disease
  2. DM
27
Q

The most common exogenous pigment is

A

Carbon (coal dust)

28
Q

Anthracosis is described to be

A

Blackening of lungs and lymph node

29
Q

List 3 endogenous pigments

A
  1. Lipofusion
  2. Maleanin
  3. Hemosiderin
30
Q

“Wear and tear pigment”

A

Lipofusion

31
Q

Lipofusion is harmful and toxic (T,F)

A

False

32
Q

Lipofusion is seen mainly in which cell

A

Cardiac monocytes

33
Q

Freckles and melasma are examples of endogenous pigment? T,F

A

True , (melanin pigment)

34
Q

The Prussian blue stains specifically stains

A

Iron in hemosedrin

35
Q

Abnormal deposition of calcium salts

A

Pathogenic calcification

36
Q

Two types of pathogenic calcification

A
  1. Dystrophic
  2. Metastatic
37
Q

Normal calcium levels are found in which pathogenic calcification type

A

Dystrophic

38
Q

Basophilic granular material

A

Dystrophic

39
Q

Normal viable tissues are found in

A

Metastatic

40
Q

High calcium levels are found in

A

Metastatic

41
Q

To which vitamin is metastatic related to

A

Vitamin D

42
Q

Decline in proliferative capacity is

A

Cellular aging

patho (3 decks)

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