Intoxications (Corrie) Flashcards

1
Q

Good history

A
  • What
  • How much
  • Active ingrediant
  • When
  • Species, breed, weight
  • treatment so far
  • symptoms, changes
  • pre-existing conditions
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2
Q

Poison control centers

A
  • case number!
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3
Q

Tox at clinic

A
  • FRONT OF LINE
  • multi-pet
    • whos the naughty one?
    • make all vomit
    • put in separate cages
  • Assess
    • exam, bloodwork (IV cath) EKG
  • Stabilize if necessary
    • respiratory distress - tube if necessary
    • seizures
    • obtunded/comotose
    • INTUBATE IF NEEDED
  • Don’t forget to do full physical
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4
Q

Testing

A
  • Min database
    • CBC
    • Chem
    • U/A: SG and sediment
  • Coagulation testing
  • Imaging
  • Specific drug testing
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5
Q

Decontamination

A
  • Prevent further absorption
  • Speed up removal
    • excretion
    • elimination
  • Tme limits
  • Extended decontamination
    • long acting and sustained release
    • enterohepatic circulation
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6
Q

Ocular decon

A
  • no time limit
    • flush for 20-30 min
  • medial to lateral
  • stain corneas
    • and stain next day
  • lubricate
    • even if negative stain
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7
Q

Topical decon

A
  • No time limit
  • Bath
    • repeatedly
    • mild dishwashing detergent
  • be conscientious about lowering body temp
    • young/old
    • debilitated
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8
Q

Oral decon dos

A
  • Things that you make vomit
    • Recent or unknown exposure
      • prefer less than 2 hours
    • slow movement through stomach
      • large meal
      • substance that stays in stomach
    • asymptomatic patient
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9
Q

oral decon don’ts

A
  • Don’t make vomit
    • corrosive agent
    • hydrocarbon toxicant: oils
    • symptomatic/unstable patient
    • medical and/or physical contraindications
      • brachycephatics
      • megaesophagus
    • emetic agents non-gratis (DON’T USE THESE)
      • syrup of ipecac
      • salt, mustard, dish detergent, milk, etc
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10
Q

Decon

Oral at home considerations

A
  • communicate that there are contraindications (DOCUMENT)
  • stable enough
  • Contraindications in hx
  • distance from hospital
  • financial concerns
  • species
  • marijauna - antiemetic properties
  • nothing safe for cats at home
  • Informed decision-document
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11
Q

Oral decon

hydrogen peroxide

A
  • Use the 3%
    • no higher concentrations
  • 1-5 mls/kg, 1 tsp, 1 tsp = 5 mls
  • can repeat 1 x wait 10-15 minutes
  • cats bad-ish
    • 10 mls/cat
  • don’t admin with explosives
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12
Q

Oral decon

Apomorphine

A
  • Apomorphine
    • dopamine receptor stimulation in CRTZ
    • not recommended for cats
    • 0.03-0.04 mg/kg IV, IM, SQ
      • can go higher
      • must be filtered
    • use in conjunctival sac
      • rinse copiously
    • anti-emetic after emesis
    • Naloxone if deleterious sides effects
      • 0.04 mg/kg IV, IM, SQ
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13
Q

Decon oral

Cats

A
  • xylazine (20mg/ml)
    • 0.44 mg/kg IM
    • be careful of 100 mg/ml
  • dexmedetomidine
    • 5 mcg/kg SQ
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14
Q

Decon

Gastric lavage

A
  • Why
    • if emesis doesn’t work
    • large amounts of material
      • bezoar, concretions, foreign body
    • when aspiration a concern
    • underlying medical/physical contraindication
    • toxicants with narrow margin safety
    • caustic and petroleum distillates
    • avoid with concurrent sharp FB
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15
Q

Decon

Gastric lavage: technique

A
  • Labor intensive and costly
    • IV cath, sedation/gen anesth, intubation
    • multiple lavages
      • activated charcoal
    • recovery and suportive care
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16
Q

Decon

activated charcoal

about

A
  • Binds instead of absorbs
  • Negative charge
  • Large surface area
  • indigestible
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17
Q

charcoal reliabel for

A

reliable

  • organic compounds
  • pesticides
  • mercury
  • fertilizer
  • many pharm drugs
  • NSAIDS
  • illegal drugs
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18
Q

Charcoal unreliable for

A
  • Unreliable
    • strong acid and bases
    • heavy metals
    • xylitol
    • alcohols
    • sodium
    • arsenic
    • iodine
    • boric acid
    • hydrocarbons
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19
Q

Charcoal

A
  • first time use with sorbitol
  • Timing
    • within an hour
    • 6 hour cutoff….?
    • long acting medication
    • enterohepatic circulation
  • Combination with cathartic
    • speed through GI
    • palatability
    • usually only first dosing
    • can cause probs
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20
Q

sorbitol contraindicated

A
  • dehyrdation
  • diabetes mellitus
  • diabetes insipidus
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21
Q

Decontamination

Activated charcoal contraindications

A
  • Oral
    • CNS depression
    • Diminished gag reflex
    • corrosive/caustic toxicant - be cautious
    • predisposed to aspiration
  • Oral or via stomach tube
    • toxicants that don’t bind
    • severe dehydration/hypovolemia
    • salt tox
    • hyperosmolar state
    • GI obstruction/perforation/ileus
    • possible endoscopy/GI sx explore
22
Q

activated charcoal

dosing

A
  • 1-5 gram/kg w/ sorbitol
    • 5-10 ml/lb
  • repeat dosing: 1-2 grams/kg (w/o sorbitol) q4-6 hours for 24 hours
    • SR/XR/LA products (NSAIDS)
    • enterohepatic circ
    • drugs that diffuse back into GI from systemic circulation
23
Q

Decon surgery

A
  • metallic foreign body
  • obstruction
24
Q

Anticoagulant rodenticides antidote

A

Vitamin K

25
Q

Acetaminophen (tylenol) antidote

A

Acetylcysteine

26
Q

Ethylene glycol (antifreeze), methanol antidotes

A
  1. Fomepizole (antizol-vet)
  2. Ethanol

*don’t use both

27
Q

Organophosphate poisoning antidote

A
  1. 2-PAM (Pralidoxime chloride) and atropine
28
Q

Benzodiazepine antagonist antidote

A

Flumazenil

29
Q

Opiate antagonist antidote

A

Naloxone

Butorphanol also a partial antagonist

30
Q

Xylazine

amitraz (dips, preventic collar)

imidazole decongestants

antidotes

A

Yohimbine - alpha2 adrenergic antagonist

Atipamezole

31
Q

Digoxin tox antidote

A
  • Digibind, Digifab
    • digoxin-specific antibody fragments
32
Q

fluids

A
  • IV fluids
    • Excretion
    • perfusion
    • hydration and azotemia
    • promotes renal vessel vasodilation
    • diuresis for nephrotoxins
  • Monitor for respiratory and cardiac stuff
  • Serial exams
    • USG
    • PCV
33
Q

GI protect

A
  • GI protection and support
    • antiemetic
      • after emesis and before AC
    • Gastric pH altering med
    • Gastric ulcer med
    • Pro-kinetics
      • regulin
      • metachlopramide
34
Q

Neurologic support

A
  • Seizures
  • Tremors
    • permethrin tox in cats
    • termorgenic mycotoxins
    • metaldehyde
  • Anti-convulsant meds, muscle relaxants, sedatives
  • Cerebral edema
  • Serotonin syndrome
    • SSRI antidepressants, ADD/ADHD meds
    • acepromazine, chlorpromazine, cyproheptadine
35
Q

Hepatoprotectants

A
  • Toxins
    • xylitol
    • blue green algae
    • NSAIDS
    • Amanita mushrooms
    • Acetaminophen
    • Sago palm
  • hepatoprotectant drugs
    • S-adenosyl-methionine (SAMe)
    • N-acetylcysteine
36
Q

IV lipid Emulsion (ILE)/

IV Fat Emulsion (IFE)

A
  • originally part of propofol vehicle
  • antidote for lipophilic drug toxicosis
    • extra label
  • ILE lipid
    • no cholesterol
    • phospholipid vesicles and triacyglycerol molecules
  • Soybean-oil based emulsions most frequently utilized
37
Q

ILE

reported to treat

A
  • Humans
    • lidocaine tox
  • vet
    • ivermectin tox
    • cholecalciferol
    • beta blockers
    • Ca channel blockers
38
Q

ILE

theory of action

A
  • Lipid sink
    • sequestration
  • Myocytes with energy substrates
    • cardiac function
  • Restores myocardial function
    • inc intracellular Ca
  • Inc fatty acid pool
39
Q

ILE use

A
  • Limit to
    • life-threatening ingestions
    • severely symptomatic patients
    • patients that don’t respond to traditional therapy
40
Q

ILE

Adverse effects

A
  • microbial contamination
  • pyogenic/colloid reaction
    • reaction to emulsion
    • anaphylactoid type reaction symptoms w/in 20 min of admin
  • Fat overload syndrome (FOS)
    • assoc with excessive vol
    • overwhelms lipid clearance mechs
    • clotting
    • pancreatitis
    • worsening of ARDS (acute respiratory distress syndrome)
41
Q

ILE

overdose tx

A
  • Carnitine (levocarnitine)
    • transport/clearnace of Fatty acids
  • Heparin CRI
    • metabolism
42
Q

Extracorporeal therapies (ECT)

A
  • Dialysis
    • kidney and tox probs
    • used for severe cases
      • +/- CS
      • High risk morbidity/mortality
      • high prob success
43
Q

ECT

mechanisms of solute removal

A
  • Diffusion
    • solute moves across semi-permeable membrane
      • by transmembrane concentration gradient
  • Convection (ultrafiltration)
    • movement of water across permeable membrane
      • resultant solvent drag due to pressure gradient
44
Q

Hemodialysis

A
  • diffusion solutes/toxins across a semipermeable membrane
    • dialysate running countercurent from blood in dialyzer
    • similar to body fluids without toxins
    • fluid hypertonic
      • to avoid absorption of water from dialysis soln
45
Q

Types of dialysis

A
  • Renal replacement therapy (RRT)
    • intermittent hemodialysis (IHD)
    • continuous renal replacement therapy (CRRT)
  • Hemoperfusion (HF)
    • blood passed over an absorbent substance
    • charcoal hemoperfusion (CH)
  • Total plasma exchange/plasmapheresis (TPE)
    • plasma component of blood separated/removed/replaced
  • Peritoneal dialysis (PD)
    • dialysis solution into abdomen
46
Q

To remember about ECT

A
  • Pharmacokinetics/toxicokinetics of many toxins unknown
  • limited evidence based studies
  • use and justification
    • human studies
    • vet case studies/reports
47
Q

Ethylene glycol (EG)

and dialysis tx

A
  • readily dialyzed like urea
  • removes EG and toxic metabolites
    • oxalic acid conversion
48
Q

NSAIDS

and dialysis tx

A
  • Enterohepatic recirculation
  • CH with HD
  • Rebound/redistribution-protein binding
49
Q

Acetaminophen

and dialysis tx

A
  • Fast plasma peak and sig liver metabolism
  • recent exposure
50
Q

Mushrooms (Amanita phalloides)

and dialysis tx

A
  • Enterohepatic recirculation
  • High affinity to AC
  • CH and HD along with TPE
51
Q

Barbiturates (phenobarb)

and dialysis tx

A
  • CH and HD
  • rebound/redistribution
  • Enterohepatic recirculation
52
Q

Lily ingestion

and dialysis tx

A
  • For AKI in cats not for prevention in intoxication