Intestinal Problems Student Flashcards
IBS
chronic abdominal pain or discomfort and alteration of bowel patterns
- diarrhea or constipation
- no known organic cause
- psychologic stressors
- GI infection; adverse reactions to food (dietary intolerances)
IBS vs IBD
IBD = disease, destructive inflammation and permanent harm to the intestines, seen in diagnostic imaging, increased risk of colon cancer
IBS = syndrome (group of symptoms), does not cause inflammation, rarely requires hospitalization, no sign of disease or abnormality during exam of colon, no increased risk for colon cancer or IBD
IBS: Dietary Intolerances
gluten
FODMAPs: fermentable oligo-, di-, and monosaccharides and polyols
IBS: Dx
based solely on sx Rome IV criteria: - presence of abdominal pain and/or discomfort at least 1 day/wk for 3 months and associated w/: -change in stool frequency -change in stool form
look at:
- health hx including psychosocial factors
- family hx
- drug hx
- diet hx
- impact on activities/life
r/o other disorders
IBS: S/Sx
GI Sx:
- abdominal pain
- nausea
- flatulence
- mucus in stool
- sensation of incomplete evacuation
Non GI Sx:
- fatigue
- HA
- sleep problems
IBS: Tx
no single effective therapy
tx considerations:
- psychological support (CBT, stress management)
- dietary changes (FODMAP diet)
- drug to regulate stool and reduce pain (opioid agonists, antispasmodics, antidepressants, antidiarrheals, or laxatives)
Diverticulosis and Diverticulitis
diverticula: saccular dilations or out-pouchings of the mucosa in the colon
common in older adults
diverticulosis: multiple, noninflamed diverticula
diverticulitis: one or more inflamed diverticus
Diverticulosis and Diverticulitis: Complications
perforation, abscess, fistula, bleeding, erosion of bowel wall, peritonitis
Diverticulosis and Diverticulitis: Etiology and Pathophysiology
- common in left (descending, sigmoid) colon
- develop at weak points; blood vessels pass through muscle layer
- cause: genetic and environmental factors
- main factors: constipation and lack of dietary fiber
- other factors: obesity, inactivity, smoking, excess alcohol use and NSAID use
D&D: S/Sx
Diverticulosis: mostly asymptomatic
- abdominal pain, bloating, flatulence, changes in bowel habits
- serious: bleeding or diverticulitis
Diverticulitis: acute pain in LLQ
- distention, decreased or absent bowel sounds, n/v, systemic sx of infection
- older adults: afrebrile, normal WBC, possible abdominal tenderness
D&D: Dx
sigmoidoscopy or colonoscopy
preferred: CT scan w/ oral contrast
- occult blood
- CBC, urinalysis
- barium enema
- blood cultures
- abdominal x-ray or chest (to r/o other causes)
D&D: Intervention
prevention:
- high fiber diet, decrease fat and red meat
- physical activity
acute diverticulitis: goal = bowel rest to reduce inflammation
- clear liquids, bed rest, analgesia
- severe sx: systemic infection, comorbidities, hospitalization, NPO, NGT, bed rest, IV fluid and antibiotics, observe for signs of abscess, bleeding, and peritonitis; advance diet as tolerated.
reoccurring diverticulitis or complications:
-surgical resection w/ anastomosis or temporary colostomy
D&D: Pt Ed
- explain condition and prescribed regimen
- high fiber diet
- fluids (at least 2 L/day)
- avoid increased intraabdominal pressure
Intestinal Obstruction
contents can’t pass through intestines
can be:
- small bowel (SBO) or large bowel (LBO)
- partial (some contents can get through)
- complete (total occlusion, needs surgery)
- simple (intact blood supply)
- strangulated (no blood supply)
Intestinal Obstruction: Types
Mechanical: physical
- SBO: surgical adhesions, hernias, cancer, strictures from Crohn’s disease, intussusception
- LBO: colorectal cancer, diverticular disease
- other: adhesions, ischemia, vovulus, Crohn’s
Non-mechanical: reduced or absent peristalsis d/t altered neuromuscular parasympathetic innervation
-paralytic ileus: abdominal surgery, peritonitis, inflammatory disordes, electrolyte imbalances, thoracic, or lumbar spinal fractures
Intestinal Obstruction: Ischemia
inadequate blood flow to bowel
ischemia results in necrosis and perforation
blood flow stops, resulting in edema and cyanosis which results in gangrene (intestinal strangulation or infarction)
requires immediate tx to avoid infection, septic shock and death
Intestinal Obstruction: Location of Obstruction
location of obstruction determines fluid and electrolyte and acid-base imbalances
high (upper duodenum): decreased HCl acid results in metabolic alkalosis
small intestine: dehydration occurs quickly
large intestine (below proximal colon): solid fecal material accumulates causing discomfort
Intestinal Obstruction: S/Sx
four hallmark:
- abdominal pain
- n/v
- distention - LBO
- constipation
order and degree depend on cause, location, and type of obstruction
Intestinal Obstruction: Dx
- imaging: abdominal x-rays, CT scan, contrast enema
- sigmoidoscopy or colonoscopy
- blood tests: CBC, blood chemistries
- increased WBC-strangulation or perforation
- increased Hct - hemoconcentration
- decreased Hgb and Hct - bleeding
- Serum electrolytes, BUN, creatinine - hydration
- metabolic alkalosis - vomiting
Intestinal Obstruction: Tx
depends on cause
- emergency surgery: strangulation or perforation
- resection of obstructed segment w/ anastomosis
- partial or total colectomy or ileostomy - obstruction or necrosis
- colonoscopy: remove polyps, dilate strictures, laser destruction and removal of tumors
monitor I&O
NGT
postop surgery similar to laparotomy
Polyps of Large Intestine
colonic polyps: arise from mucosal surface and project into lumen
- sessile: flat, broad-based, attached to wall
- pedunculated: attached to wall by thin stalk
- increase incidence with age; especially proximal colon
- commonly asymptomatic (occult blood & bleeding)
Types of Polyps
hyperplastic: non-cancerous; less than 5mm
- no symptoms
- other benign: inflammatory, lipomas, juvenile
adenomatous: neoplastic
- removal decreases risk of cancer
Familial Adenomatous Polyposis (FAP)
- autosomal dominant and recessive; DNA testing
- colorectal screening at puberty and annually age 16
may have hundreds or thousands of polyps that will become cancerous by age 40
requires removal of colon and rectum by age 25 (proctocolectomy w/ IPAA or ileostomy)
risk for other cancer (lifetime surveillance required)
Polyps: Dx
colonoscopy sigmoidoscopy barium enema virtual colonoscopy (CT or MRI) all polyps are abnormal and removed (polypectomy)
Colorectal Cancer
third leading cause of cancer related deaths
Hereditary Nonpolyposis Colorectal Cancer (HNPCC) or Lynch Syndrome:
- autosomal dominant disorder
- DNA testing available to detect gene mutations
- increased risk of other organ cancers
- need annual colonoscopy
CRC: Risk Factors
no single risk factor
highest risk: first degree relatives w/ CRC and people with IBD
-family hx of CRC or familial adenomatous polyposis (FAP)
-hereditary form
-Abnormal KRAS gene (oncogene)
other: obesity, smoking, more than 7 servings red meat/wk, more than 4 alcohol drinks/wk, diabetes
CRC: S/Sx
sx do not usually appear until disease is in advanced stages
- common: iron-deficiency anemia, rectal bleeding, abdominal pain, change in bowel habits
- early: none or nonspecific; fatigue, weight loss
- advanced: abdominal tenderness, palpable mass, hepatomegaly ascites
CRC: Dx
regular screening for polyps and cancer from ages 45-75 years of age by one of the following exams:
- flexible sigmoidoscopy every 5 years
- colonoscopy every 10 years
- double-contrast barium enema every 5 years
- CT colonography every 5 years
annual screening primarily for cancer
- high sensitivity fecal occult blood test (FOBT) or
- fecal immunochemical test (FIT): test for blood in the stool, must be done frequently to catch intermittent bleeding common with tumors
stool DNA every 3 years - DNA mutations
colonoscopy = gold standard
- entire colon is examine; biopsy specimens
- polyps removed and sent to lab
- every 10 years starting at 45
- every 5 years starting at 40 if higher risk (1º relative w/ CRC) or 10 years earlier than when youngest relative diagnosed
CRC: Tx
correlates w/ pathologic staging of disease
surgery:
- resect tumor
- remove lymph nodes that drain that area
non-resectable tumors or metastasis:
- surgery is palliative, relieves obstruction or controls bleeding
- chemo and radiation, control the spread and provide pain relief
Bowel Resection and Ostomy Surgery: Indications
- remove cancer
- repair perforation, fistula, or traumatic injury
- relieve obstruction or stricture
- treat an abscess, inflammatory disease (Diverticulitis) or hemorrhage