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Intestinal pathology (wk 4) Flashcards

1
Q

List the components of the small intestine

A

o Duodenums
o Jejunum
o Ilium

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2
Q

List the components of the large intestine

A 
o	Caecum
o	Ascending colon
o	Transverse colon
o	Descending colon
o	Sigmoid Colon
o	Rectum
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3
Q

What is the function of the digestive system?

A

Digestion and absorption

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4
Q

What is the function of bile?

A

It is an emulsifier

Further absorption

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5
Q

What is the function of pancreatic enzymes?

A

Further breakdown of food into smaller units

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6
Q

What is classified as diarrhoea?

A

When faeces is more than 500ml

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7
Q

What are some functions of microorganisms?

A

Assist digestion
Produce vitamins
Compete for space/nutrition/oxygen

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8
Q

What are the 4 general layers seen in the intestine?

A

Mucosa
Submucosa
Muscle
Serosa

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9
Q

T/F:

Mature B and T cells are found in Peyer’s Patches

A

False

They are naive

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10
Q

T/F:

B and T cells in the villi are mature

A

True

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11
Q

T/F:

Intra epithelial lymphocytes are mostly CD4 T cells

A

False

Mostly CD8

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12
Q

T/F:

Lamina Properia Lymphocytes are mostly CD4 and B cells

A

True

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13
Q

Which cranial nerve innervates the gut?

A

Vagus nerve

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14
Q

What is the function of the muscular layer?

A

Peristalsis

Makes sure contents move from proximal to distal

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15
Q

What predominantly covers villi?

A

Mature absorptive enterocytes

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16
Q

T/F:

Villi are long lived

A

False

• Live only for a few days, die and are shed into the lumen to be digested and absorbed

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17
Q

What are crypts?

A

moat-like invaginations of the epithelium around the villi, and are lined largely with younger epithelial cells which are involved primarily in secretion

• Toward the base of the crypts are stem cells, which continually divide and provide the source of all the epithelial cells

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18
Q

Which part of the villi is most crucial for absorption?

A

Tip ;)

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19
Q

What is the function of crypts?

A

o Secrete ions and water,
o Delivery IgA
o Anti-microbial peptides to the lumen,
o Serve as the site for cell division and renewal

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20
Q

T/F:

Plasma cells in the intestine are mostly IgM positive

A

False
Mostly IgA positive
Then IgG

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21
Q

T/F:

Small intestine is mostly involved in reclaiming luminal water and electrolytes

A

False
Large intestine is mostly involved in reclaiming luminal water and electrolytes
Small intestine is more focused on absorption of nutrients

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22
Q

T/F:

There are villi in the colonic mucosa

A

False
No villi
Flat

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23
Q

T/F:

The intestinal mucosa is the most vulnerable site for pathogenic invasion

A

True

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24
Q

Describe what happens when an antigen enters the area

A

Antigen is taken to Peyer’s patch by an antigen presenting cell to activate B and T cells

Drains through lymph nodes and through the blood circulation

Lymphocytes come back to the gut using a homing mechanism (express a molecule that matches the mucosa adhesion molecule ligand in the gut)

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25
Why do children experience rotavirus more than adults?
Their immune system isn't as developed as adults | Therefore more susceptible
26
T/F: | Rotavirus is a wheel-like virus and is an opportunistic pathogen
True
27
T/F: | Rota virus is enveloped and unstable in the environment
False no envelope Stable in environment dsRNA
28
What is the most common cause of severe diarheoa in children?
Rota virus
29
List some symptoms of rota virus
Fever Vomiting watery poop Abdominal pain
30
How is rota virus transmitted?
Fecal-oral route | Ingestion of contaminated food/water
31
How can you diagnose someone with rota virus?
Rapid antigen detection in stool specimens Enzyme immunoassay RT-PCR
32
What barrier does rota virus face in the intestine?
Inhospitable gastric environment
33
Describe some of the hisopathological changes when someone is infected with rota virus
Notable changes in mucosal surfaces Villi are shortened, blunted, appear atrophic Enterocytes become cuboidal Lamina propria is infiltrated with mononuclear cells
34
List some symptoms of inflammatory bowel disease
* Abdominal cramps and pain * Diarrhea * Weight loss * Fecal bleeding
35
T/F: | Irritable bowel syndrome belongs to the Inflammatory Bowel Disease Family
False | Not the same
36
What are the two types of inflammatory bowel disease?
Ulcerative colitis | Chron's disease
37
T/F: | Inflammatory bowel disease is a short term disease
False long term can start as early as 10 years old
38
What are some possible causes of inflammatory bowel disease?
• Genetic factors (HLA-DR1/DQw5…) • Environmental factor o Pollution, pesticides etc o Need individual susceptibility o Ie. Need genetics + environmental factors • Dysregulated immune response Not really too sure
39
T/F: | Inflammatory bowel disease consists of too much anti-inflammatory and not enough pro-inflammatory
False | Too much pro-inflammatory
40
There are 3 types of possible treatments people use to assist living with inflammatory bowel disease what are they?
• Anti-inflammatory drugs o Used to decrease the inflammation caused by the disease, e.g. anti-TNF • Immunosuppressive agents o To restrain the immune system from attacking the body's own tissues and causing further inflammation • Probiotics o IBD patients have disturbed gut flora o 10% of patients feel much better after this treatment
41
Describe some macroscopic observations you might see when looking at the colon of a patient suffering chron's disease
``` Pus Abcess Thickened intestinal wall Narrow lumen Exudate Blood ```
42
Why might people lose weight if they suffer chron's disease?
Inflammation is energy hungry combined with the fact that they aren't absorbing nutrients efficiently
43
What are some microscopic features of Chron's disease?
``` Architecture destroyed Thickened Reduced epithelial cells (ulceration) Vascularisation Leukocyte accumulation Loose connective becomes solid Granuloma forms Fissure/splitting due to chronic inflammation No cryps Neutrophil infiltration ```
44
Which parts of the digestive system does Ulcerative collitis affect?
Descending colon and sigmoid colon
45
What are some macroscopic observations you can make about ulcerative collitis?
``` Diffuse Hemorrhage Lack of intestinal folds= bad absorption, causes diarrhea Ulceration Pseduopolyps ```
46
What are some microscopic features of ulcerative collitis?
No cryps Chronic inflammation New vascularization particularly in sub mucosa (it should be loose connective) Only really affects 2 layers (chron’s affects 4 layers) Lymphoid aggregates Submucosa gradually becomes solid Plasma cells, neutrophils, macrophages Muscle and serosa layers are not affected
47
T/F: | Ulcerative collitis is transmural
False | Only affects mucosa and submucosa
48
T/F: | Granulomas are seen in ulcerative collitis
False | They are seen in Chron's disease
49
What is an issue with surfically removing parts of the intestine in patients suffering ulcerative collitis?
The disease affects descending colon and sigmoid colon so you lose a direct link to the anus
50
T/F: | You can survive without eating foods with fat in them
False | Need in moderation
51
What is malansorption?
• Malabsorption is difficulty in the digestion or absorption of nutrients from food substances from the small intestine
52
What is gastritis?
struggle to digest the food
53
If you cant digest food you can't ____ food
absorb
54
What are the two common forms of malabsorption?
• Protein-energy malnutrition o Inadequate availability or absorption of energy and proteins in the body o Not often seen in Australia o Seen more in rural areas, Africa • Micronutrient malnutrition o Inadequate availability of some essential nutrients (vitamins & trace elements) that are required by the body in small quantities o People on ships travelling long distances= lack of vitamin c, noticed they were bleeding a lot
55
List some of the main causes of malabsorption
• Celiac disease (next slide) • Liver disease o Cirrhosis, hepatitis, and gallstones o Cirrhosis from alcohol abuse or viral (makes it nodule) o Gallstone: compromises your absorption, disturbs bile production (this is needed for absorption) • Cystic fibrosis • Lactose intolerance o Primary and Secondary forms o Lack lactase and can’t break down lactose • Chronic pancreatitis o Need pancreatic enzymes for digestion o Enzymes break things down into smaller constituents • Inflammatory bowel disease (previous lecture) • Intestinal infections (Bacterial or parasitic) o You are competing with the microorganism o They’ve already inflamed your digestive system o They absorb nutrients before you get a chance to • Specific medications that affect the intestines • Surgery of the stomach or bowels o Removal of parts of the stomach/bowels/pancreas may compromise digestion/absorption
56
How may a gall stone contribute to malabsorption?
Disrupts bile production which is needed for absorption
57
A patient is diagnosed with coeliac disease. What kinds of symptoms may they be experiencing?
loose stools, flatulence, abdominal discomfort and distensionstools are bulky, malodorous and often difficult to flush villous atrophy
58
If you take a histological sample and the sample appears quite dark (H and E stain) what does this mean?
Lots of nuclei are being stained | Cellular infiltration
59
What happens when villi are 'flat tip'
‘flat tip’= reduce surface area, decreases absorption efficiency
60
What is B12 essential for and what is its main source?
• Essential for normal nervous system function and blood cell production (RBCs) • The main sources of vitamin B12 o Eggs & dairy products
61
T/F: | B12 can be absorbed without any additional factors
False | Needs an intrinsic factor to be absorbed by the body
62
Pernicious anemia is caused by ______ deficiency
Vitamin B12 * It would show up on a blood test because of the large immature red blood cells that are present. * These large red blood cells are very inefficient at carrying oxygen
63
R-binder is produced by ____
saliva
64
Explain how B12 is absorbed
B12 enters the body bound to a protein In the stomach, pepsin separates B12 from the protein and now the R-binder (produced by the saliva) can bind to B12 In the duodenum, the pancreas will secrete enzymes and R-binder will release from B12 The stomach produces an intrinsic factor and it binds to B12 The terminal ilieum has receptors for the intrinsic factor B12 can now be absorbed
65
T/F: | R Binder is produced by the stomach
False | Produced by the saliva
66
T/F: | The pancreas produces an intrinsic factor that binds to B12 to allow for its absorption
False | the stomach produces the intrinsic factor
67
How would pancreatitis affect the absorption of B12?
don’t have enzymes to break down R-binder and B12, then B12 can’t bind to intrinsic factor produced by the stomach
68
What does the stomach produce in terms of B12 absorption?
Produces pepsin to break apart B-12 from the protein | Produces an intrinsic factor to bind to B12
69
What are some symptoms of B12 deficiency?
``` • Anemia • Fatigue • Weakness • Constipation o Nerve deficiency/nerve development deficiency o Don’t send good messages to the gut ``` • Loss of appetite o When you’re sick you don’t feel like eating o Can be psychological • Weight loss o Don’t have an appetite o Struggle to absorb nutrients

CPAT (9 decks)

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