Interstitial Lung Disease

Question 1

Most common causes of UIP

Answer 1

Idiopathic (linked to smoking)
Drug toxicity
Rheumatoid arthritis

Question 2

Histologic findings in UIP

Answer 2

Chronic alveolar inflammation

Interstitial fibroblastic foci

Question 3

Features of definite UIP

Answer 3

Subpleural, basal predominant reticulation
Honeycombing

(diffuse or asymmetric pattern is allowed)

Question 4

Features of probable UIP

Answer 4

Subpleural, basal predominant reticulation

BUT

No honeycombing

Question 5

Clinical syndrome of UIP with an unknown cause

Answer 5

Idiopathic pulmonary fibrosis

worst prognosis of any cause of UIP

Question 6

Stereotypical patient with UIP

Answer 6

Male smoker > 50 years old

Presents with chronic dyspnea and dry cough

Question 7

What typically responds to steroids?

NSIP or UIP

Answer 7

NSIP

and has better 5-year survival

Question 8

What is NSIP almost always associated with?

Answer 8

Underlying collagen vascular disease

can also be caused by drug toxicity

Question 9

Most common collagen vascular diseases associated with NSIP

Answer 9

Scleroderma
Dermatomyositis
Lupus
Mixed connective tissue disorder

Question 10

Histologic findings in NSIP

Answer 10

Chronic alveolar inflammation

Thickened alveolar walls

Question 11

Imaging features of NSIP

Answer 11

Subpleural, basal predominant reticulation

Peribronchial GGOs

Question 12

Specific feature of NSIP that is not present in UIP

Answer 12

Immediate subpleural sparing

Question 13

Imaging finding that mimics honeycombing

Answer 13

Traction bronchiectasis