Interleukins Flashcards

1
Q

IL-1 source

A

Macrophages

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2
Q

IL-2 source

A

T cells

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3
Q

IL-3 source

A

T cells

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4
Q

IL-4 source

A

Th2 cells

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5
Q

IL-4 source

A

Th2 cells

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6
Q

IL-6 source

A

Macrophages

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7
Q

IL-8 source

A

Macrophages

T cells

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8
Q

IL-10 source

A

Th2 cells

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9
Q

IL-12 source

A

Macrophages

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10
Q

IL-1 effects

A

Increase neutrophil and macrophage migration

Increase acute phase reactants, fever, and shock

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11
Q

IL-2 effects

A

Increase T cell activation and proliferation.

Increase NK cell and macrophage activity

Increase B cell growth

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12
Q

IL-3 effects

A

Increase hematopoiesis

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13
Q

IL-4 effects

A

Increase Th2 cell differentiation

Increase B cell growth

Increase isotype switching to IgE

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14
Q

IL-5 effects

A

Increase differentiation of eosinophils

Increase isotype switching to IgA

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15
Q

IL-6 effects

A

Increase T and B cell growth

Increase osteoclastic activity

Increase acute phase reactants and fever

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16
Q

IL-8 effects

A

Increase neutrophil activation and chemotaxis

17
Q

IL-10 effects

A

Decrease Th1 cell differentiation

Decrease cell-mediated immunity and APC activity

Increase B cell function

18
Q

IL-12 effects

A

Increase Th1 cell differentiation

Increase NK cell and CD8+ T cell activation