Immunosuppressants Flashcards by Dillon Pryor | Brainscape

Q

Mechanism:

Cyclosporine

A

Calcineurin inhibitor

Binds cyclophilin → blocks T-cell activation by preventing IL-2 transcription

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mechanism:

Tacrolimus (FK506)

A

Calcineurin inhibitor

Binds FK506 binding protein (FKBP) → blocks T-cell activation by preventing IL-2 transcription

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mechanism:

Sacrolimus (Rapamycin)

A

mTOR inhibitor - binds FKBP → blocks T-cell activation and B-cell differenciation by preventing response to IL-2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mechanism:

Basiliximab

A

Monoclonal antibody - blocks IL-2R

How well did you know this?

1

Not at all

2

3

4

5

Perfectly