Interactions

Question 1

How does iron differ to copper and zinc?

Answer 1

There are clinical tests for it.

Question 2

What form of iron binds to ferritin and transferrin and why?

Answer 2

Fe(III) as binds much more strongly.

Question 3

What is significant concerning inborn errors of metal metabolism?

Answer 3

On average ~100 different proteins knocked out in a given individual - only shows up if essential.
The metals themselves aren’t important but rather the proteins they bind.

Question 4

Why do we have Cu chaperones but no Zn chaperones?

Answer 4

Cu = strongest bonder so potential to create havoc if binds where shouldn’t (AND redox active).

~3000 Zn proteins - not feasible to use chaperones.

Question 5

How do we think Cu and Zn get into SOD?

Answer 5

Cu has much lower concentration - is it put in by a chaperone before zinc?

Question 6

What protein does MTF-1 serve as a transcription factor for?

Answer 6

Hepcidin.