Cu Proteins Flashcards
What is lysyl oxidase?
Important for cross-linking of structural proteins e.g. collagen and elastin.
Give three Cu-dependent enzymes.
Dopamine B-hydroxylase (catecholamine production)
Tyrosinase - melanin production
a-amidating monooxygenase - activation of peptide hormones.
What important enzyme is Cu a cofactor for?
PAM - involved in amidating neuropeptides to functional form e.g. gastrin, neuropeptide Y, pancreastatin.
How do hephaestin and Cp differ?
Heph - found on intestinal epithelial cells.
Cp - in serum.
What is the role of Cu in CuZnSOD?
Zn is structural factor while Cu involved in catalysis.
What is COMMD1?
scaffold protein - protects ATP7 from lysosomal degradation and triggers translocation from ER to TGN.
Where is ATP7A predominantly expressed?
placenta, heart, BRAIN, INTESTINE.
Where is ATP7B predominantly expressed?
liver (some extent in BRAIN, kidney and mammary tissue).
