Integumentary System Flashcards
Avascular, keratinized stratified squamous epithelium layer of skin is ______.
Derived from _____
Epidermis
Ectoderm
Highly vascular, connective tissue layer of skin is _____.
derived from ______
Dermis
Mesoderm
Adipose tissue layer deep to skin
Hypodermis/Subcutaneous layer
Hairless skin found on palms and soles only?
Number of layers?
Thick skin
5
Skin with hair follicles?
Number of layers?
Thin Skin
4
Epidermis layers (deep to superficial)
- Stratum Basale
- Stratum Spinosum
- Stratum Granulosum
- Stratum Lucidum (thick skin only)
- Stratum Corneum
“Bad Sprinters Get Leg Cramps”
Keratinocytes (___%) produce ____ and form a _____.
85%
Keratins
Water Barrier
Melanocytes (__%) produce _____ that are made and stored in _____.
These rounded cell bodies are in the _____ and the long processus extend between keratinocytes in the ______
5%
Melanin (pigment)
Melanosomes
Stratum Basale
Stratum Spinosum
Langerhans’ cells (__%) are _____ cells
2-5%
Antigen-presenting
Merkel’s Cells (__%) are ____ cells
6-10%
Mechanoreceptor
Keratins form filaments called ____/_____/_____
Keratin filaments
Intermediate Filaments
Tonofilaments
Keratinocytes participate in formation of water barrier via production of _____
Lamellar Bodies
Mitotically active layer of epidermis (stem cells -> keratinocytes); production of intermediate (keratin) filaments begins here
Stratum Basale
Cytoplasmic processes for attachment via desmosomes in this epidermis layer called ______.
Intermediate filaments here are grouped into bundles called _____.
Production of _____ and _____ also begins in this layer.
Stratum Spinosum
Tonofibrils
Keratohyalin Granules
Lamellar Bodies
This epidermis layer known as _____ is intensely basophilic.
It contains _____ that bundle tonofilaments into tonofibrils
Here, conversion of granular cells into cornified cells happens (AKA ____)
____ are also release here.
Stratum Granulosum
Keratohyalin Granules
Keratinization
Lamellar Bodies
Cells are sloughed off at this epidermal layer known as _____
Stratum Corneum
Accumulates over keratinocyte nuclei to protect DNA from UV radiation
Melanin
Langerhans’ Cells are found within the _____ and derived from ____
Stratum Spinosum
Bone marrow
Merkel’s Cells are located within the ____ and form ____ with afferent nerve fibers
Stratum Basale
Merkel’s Corpuscle
Most common skin cancer. Slow growing tumor. Resembles cells of stratum basale.
Basal Cell Carcinoma
Second most common skin cancer. Highly atypical cells at all epidermis levels.
Squamous Cell Carcinoma
Most serious skin cancer. Melanocyte origin. Irregularly pigmented, multicolor lesion.
Malignant Melanoma
Loose connective tissue layer of Dermis known as ____ with finger-like protrusions known as _____
Papillary Layer
Dermal Papillae
Dense irregular connective tissue Dermis layer
Reticular Layer