Integumentary Flashcards
largest single organ of the body ; 15%-20% of total body weight
Skin
two major layers of skin
Epidermis and Dermis
an epithelial layer of ectodermal
origin ; the one directly observed physically
Epidermis
a layer of mesodermal connective
tissue ; the thickest layer, divided into the
papillary layer and reticular layer
Dermis
Structures that are embedded in the skin but
otherwise considered as a separate organ/tissue
Epidermal derivatives of the skin
The four epidermal layers of the skin
Hair follicles and hair
Sweat (sudoriferous) glands
Sebaceous glands
Nails
Functions of the Skin
Protective
Sensory
Thermoregulatory
Metabolic
Sexual signaling
provides a physical barrier against thermal
and mechanical insults
Protective
allow skin to
constantly monitor the environment
Sensory
skin’s insulating components and its
mechanisms for accelerating heat loss
Thermoregulatory
Cells of skin synthesize vitamin D3, needed in
calcium metabolism and proper bone
formation
Metabolic
effects of sex pheromones produced by
the apocrine sweat glands
Sexual signaling
consist mainly of a stratified squamous
keratinized epithelium composed of cells called keratinocytes
Epidermis
Cells in Epidermis
Keratinocytes
Langerhan cells
Melanocytes
Merkel cells
production of the protein
keratin ; Predominant cell type of the epidermis
Keratinocytes
skin macrophage ; It possesses characteristic, tennis racquet-shaped Birbeck granules ; Most clearly seen in the spinous layer
Langerhan cells
produces melanin ; Neural crest-derived ; dendritic cell that is scattered among the
basal cells of the stratum basale
Melanocytes
granules that contain melanin
Melanosomes
precursor of melanin
Tyrosine
Epithelial tactile cells ; Function in cutaneous sensation ; Abundant in highly sensitive skin like that of fingertips and at the bases of some hair follicles ; Located in the stratum basale
Merkel cells
Thick skin
Palms and soles
Thin skin
Elsewhere on the body
─stratum basale
─stratum spinosum
─stratum granulosum
─stratum lucidum
─stratum corneum
Layers of Epidermis
Basal layer (stratum basale)
Spinous layer (stratum spinosum)
Granular layer (stratum granulosum)
Stratum lucidum
Stratum corneum
single layer of basophilic cuboidal or
columnar cells ; Characterized by intense mitotic activity and contains ; Important feature – cytoskeletal keratins
Basal layer (stratum basale)
Thickest layer, especially in the epidermal
ridges ; Synthesis of much keratin and other proteins takes place ; exhibit spinous processes
Spinous layer (stratum spinosum)
Keratinocytes in this layer contain numerous
keratohyalin granules
Granular layer (stratum granulosum)
important in the aggregation of the keratin
filaments ; cysteine rich and histidine rich proteins considered as the precursors of the protein filaggrin ; when released by exocytosis would usually
produce a layer that is lipid rich around the cell
Lamellar granules