Insulins

Question 1

recombinanat human insulins

Answer 1

Humulin and Novolin

Question 2

humulin is made of

Answer 2

e. coli

Question 3

novolin is made of

Answer 3

transformed yeast

Question 4

very short acting insulins

Answer 4

lispro, aspart, glulisine
15 mins , 6-8 / 3-5 hours

Question 5

short acting insulins

Answer 5

regular insulin (humalin/novolin)
30 min-1 hr, 8-12 hours

Question 6

intermediate onset / action insulins

Answer 6

NPH
1-1.5 hour, 24 hours

Question 7

long acting insulins

Answer 7

glargine, detemir, degludec
1-2 hours, >24 hours

Question 8

lispro brand

Answer 8

Humalog

Question 9

aspart brand

Answer 9

Novolog

Question 10

glulisine brand

Answer 10

Apidra

Question 11

glargine brand

Answer 11

Lantus

Question 12

detemir brand

Answer 12

Levemir

Question 13

degludec brand

Answer 13

Tresiba

Question 14

lispro insulin (brand, onset, modification)

Answer 14

Humalog, 15 mins, P28 and K29 proline and lysine switch to prevent dimerization

Question 15

aspart insulin (brand, onset, modification)

Answer 15

Novolog, 15 mins, P28 becomes aspart in beta chain to prevent dimerizaton

Question 16

glulisine insulin (brand, onset, modification)

Answer 16

Apidra, 15 mins, Asn 3 and Lys 29 switched to lysine and glutamic acid

Question 17

glargine insulin (brand, onset, modification)

Answer 17

Lantus, quick and 24 hours, asn 21 to gly ON ALPHA and add two arg on beta

Question 18

detemir insulin

Answer 18

Levemir, quick onset 24 hours, 30 on beta chain deleted and lys 29 is myristylated