Hockermanm

Question 1

what is the substrate protein for factor IIa?

Answer 1

fibrinogen/fibrin

Question 2

Hemophillia A is a deficiency in what

Answer 2

8

Question 3

Hemophillia B is a deficiency in what

Answer 3

9

Question 4

where are clotting factors produced?

Answer 4

liver (except von Willebrand)

Question 5

where is von Willebrand produced?

Answer 5

endothelium, subendothelium, megakaryoctyes

Question 6

liver disease can have a _____ effect on anticoag

Answer 6

unpredictable

Question 7

recalcification (bleeding time)

Answer 7

2-4 minutes

Question 8

aPTT time and use

Answer 8

26-33 seconds
test heparin efficacy

Question 9

prothrombin time PT

Answer 9

11-14 seconds
test warfarin efficacy

Question 10

warfarin inhibits factors __

Answer 10

2, 7, 9, 10, protein C and S

Question 11

drugs that increase warfarin effect
increase INR

Answer 11

broad spectrum antibiotics
metronidazole, amiodarone, fluconazole, bactrim, ciprofloxacin

Question 12

drugs that decrease warfarin effect decrease INR

Answer 12

rifampin
vitamin K

Question 13

warfarin overdose? no major bleeding

Answer 13

vitamin K if INR >10

Question 14

warfarin overdose? major bleeding

Answer 14

prothrombin complex concentrate with vitamin K

Question 15

heparin reversal agent

Answer 15

protamine sulfate

Question 16

reversal agent for apixaban and rivaroxaban

Answer 16

andexanent alpha

Question 17

black box warning andexanet alpha?

Answer 17

thrombolytic events

Question 18

peptide of leach saliva gland

Answer 18

hirudin

Question 19

lepirudin binding?

Answer 19

irreversible

Question 20

bivalirudin binding?

Answer 20

reversible

Question 21

argatroban binding

Answer 21

reversible

Question 22

dabigatran reversal agent

Answer 22

idarucizumab

Question 23

what kind of molecule is tPA

Answer 23

serine protease

Question 24

what does plasmin do?

Answer 24

proteolytic enzyme that digests fibrin and fibrinogen

Question 25

what is tPA inhibited by?

Answer 25

PAI-1 and PAI-2

Question 26

indications for thrombolytic therapy

Answer 26

MI, ischemic thrombolytic stroke, PE

Question 27

fibrinolytic drugs

Answer 27

alteplase, reteplase, tenecteplase

Question 28

which fibrinolytic has mutations

Answer 28

tenecteplase

Question 29

what do the mutations in tenecteplase do?

Answer 29

increase 1/2 life
reduce inhibition by PAI
enhance activity at thrombi

Question 30

which fibrinolytic does not bind fibrin directly?

Answer 30

reteplase

Question 31

antifibrinolytic drugs

Answer 31

aminocaproic acid
tranexamic acid

Question 32

three molecules secreted by platelets

Answer 32

TXA2
ADP
5 HT

Question 33

vasoconstricters?

Answer 33

TXA2 and 5 HT

Question 34

GP IIb/IIIa role

Answer 34

bind fibrinogen and then fibrinogen crosslinks platelets together to form a clot

Question 35

what does aspirin do

Answer 35

COX-1 inhibitor which decreases TXA2
irreversible inhibition
prophylaxis and treatment of arterial thromboembolic disorders

Question 36

selective cox 2 inhibitors have what risk

Answer 36

cardiovascular risk since they don’t prevent synthesis of TXA2

Question 37

prasurgel risks

Answer 37

bleeding, dont use in old

Question 38

ticagrelor binding

Answer 38

reversible

Question 39

clopidogrel and prasugrel binding

Answer 39

irreversible

Question 40

which adp inhibitros are prodrugs

Answer 40

clopidogrel and prasugrel

Question 41

prasugrel cyps

Answer 41

esterases and CYP 3A4/2B6

Question 42

absiximab increased risk of

Answer 42

bleeding

Question 43

absiximab half life

Answer 43

long

Question 44

vorapaxar

Answer 44

PAR inhibitor
reversible

Question 45

PDE3 inhibitors?

Answer 45

cilostazol, dipyridamole, oppose P2Y12 action