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Clin-Med B3 > Insulin Rx > Flashcards

Insulin Rx Flashcards

0
Q

Metformin- SE

A

-Lactic acidosis**-> cannot be used for renal failure

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1
Q

Biguanides

A

Metformin

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2
Q

1st generation SFU

A
  • Tolbutamide

- Chlorpropamide

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3
Q

2nd generation SFU

A
  • Glyburide
  • Glimepiride
  • Glipizide
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4
Q

SFU- cc

A

Close K+ channel in beta cell membrane-> depolarize-> triggering of insulin release via increased Ca++ influx
-require islet function-> only for type2

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5
Q

2nd generation SFU- SE

A

Hypoglycemia

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6
Q

1st generation SFU- SE

A

Disulfiram like effects

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7
Q

Glitazones

A

Thiazolidinediones

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8
Q

TZD

A
  • Pioglitazone

- Rosiglitazone

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9
Q

TZD- cc

A

increase insulin sensitivity in peripheral tissue by binding to PPAR-y nuclear transcription regulator

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10
Q

a-glucosidase inhibitor

A
  • Acarbose

- Miglitol

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11
Q

a-glucosidase inhibitor- cc

A

Inhibit intestinal brush-border a-glucosidases

-> delayed sugar hydrolysis and glucose absorption

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12
Q

Amylin analogs

A

Pramlintide

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13
Q

Amylin analog- cc

A

Decrease glucagon

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14
Q

GLP-1 analogs

A
  • Exenatide

- Liraglutide

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15
Q

GLP-1 analogs- cc

A

Incretin- mimetics
Increase insulin
Decrease glucagon release

16
Q

DPP-4 inhibitors

A
  • Linagliptin
  • Saxagliptin
  • Sitagliptin
17
Q

DPP-4 inhibitors- cc

A

Inhibit incretin
increase insulin
Decrease glucagon

18
Q

Short acting Insulin

A
  • Lispro
  • Aspart
  • Glulisine
  • Regular
19
Q

Intermediate acting Insulin

A

-NPH

20
Q

Long acting Insulin

A
  • Glargine
  • Detemir
  • Degludec

Clin-Med B3 (17 decks)

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