Insulin Rx Flashcards
Metformin- SE
-Lactic acidosis**-> cannot be used for renal failure
Biguanides
Metformin
1st generation SFU
- Tolbutamide
- Chlorpropamide
2nd generation SFU
- Glyburide
- Glimepiride
- Glipizide
SFU- cc
Close K+ channel in beta cell membrane-> depolarize-> triggering of insulin release via increased Ca++ influx
-require islet function-> only for type2
2nd generation SFU- SE
Hypoglycemia
1st generation SFU- SE
Disulfiram like effects
Glitazones
Thiazolidinediones
TZD
- Pioglitazone
- Rosiglitazone
TZD- cc
increase insulin sensitivity in peripheral tissue by binding to PPAR-y nuclear transcription regulator
a-glucosidase inhibitor
- Acarbose
- Miglitol
a-glucosidase inhibitor- cc
Inhibit intestinal brush-border a-glucosidases
-> delayed sugar hydrolysis and glucose absorption
Amylin analogs
Pramlintide
Amylin analog- cc
Decrease glucagon
GLP-1 analogs
- Exenatide
- Liraglutide
GLP-1 analogs- cc
Incretin- mimetics
Increase insulin
Decrease glucagon release
DPP-4 inhibitors
- Linagliptin
- Saxagliptin
- Sitagliptin
DPP-4 inhibitors- cc
Inhibit incretin
increase insulin
Decrease glucagon
Short acting Insulin
- Lispro
- Aspart
- Glulisine
- Regular
Intermediate acting Insulin
-NPH
Long acting Insulin
- Glargine
- Detemir
- Degludec
