Insulin Analogs

Question 1

Insulin

Answer 1

• dimerizes upon subcutaneous injection
• absorption is delayed by 30 min
  Onset: .5-1hr / Peak: 1 -2 / Duration: 5-7

Question 2

Lispro (Humalog)

Answer 2

• synthetic insulin analog with 2 aa’s switched, does not dimerize
• absorbed more rapidly

Question 3

NPH insulin (Isophane)

Answer 3

• protamine-zinc-insulin complex

- insulin released slowly at site of injection

Question 4

Glargine and determir

Answer 4

• aa differences cause precipitation upon injection
• slowly dissolves over time
• NO PEAK