insulin action Flashcards
1
Q
insulin receptor is what type
A
tyrosine kinase
2
Q
receptor activation leads to what? what does this lead to?
A
autophosphorylation, creation of binding sites for secondary messengers
3
Q
Role of insulin in glucose uptake
A
promotes the translocation of GLUT1 and 4 to the cell membrane in fat and muscle (liver is independent, therefore takes up all the glucose in DM)
4
Q
role of insulin in glucose storage and release
A
inhibit liver gluconeogenesis (PEPCK)
inhibit of glycogenolysis (glycogen phosphorylase)
promotion of glycogen synthesis (glycogen synthase)
5
Q
role of insulin in fatty acid storage and synthesis
A
promotion of free FA lipolysis -- LPL promotion of triglyceride synthesis inhibition of stored FA lipolysis -- HSL stim of FAS Suppression of CPT1 fatty acid oxidation
6
Q
protein synthesis and storage
A
promotes initiation and elongation factors
suppression of catabolism
