Instrumentation in Hemostasis Testing

Question 1

Electromechanical

Answer 1

Mechanical clot detection that incorporates a change in electrical conductivity between 2 metal electrodes immersed in a solution.
Another method of mechanical clot detection involves monitoring the movement of a steel ball within the test solution using a magnetic sensor

Question 2

Optical density

Answer 2

Photo-optical clot detection measured by a change in optical density of a test sample

Question 3

Chromogenic clot detection

Answer 3

Because coagulation cascade is a series of enzymatic reactions, the enzyme of interest cleaves the chromogenic substrate at a specific site, releasing the chromophore tag.

Question 4

Immunologic detection

Answer 4

Latex particles are coated with a specific antibody against the antigen being determined.