Anticoagulant Drugs

Question 1

Do not dissolve clots, but stop existing clot from worsening.

Answer 1

Anticoagulant drugs

Question 2

Treated with antiplatelet drugs

Answer 2

Arterial

Question 3

Treated with Heparin

Answer 3

Venous

Question 4

Injection only-IV or Sub Q.
Potentiates formation of complexes between antithrombin and other factors
Increases antithrombins ability to neutralize serine proteases.
Rapid inhibitor, decreases production of complexes.
Monitored by APTT and ACT.
LMWH and fondaparinux:
Subcutaneous injection.
Catalyzes interaction of antithrombin and Xa.
Does not require rountine monitoring.
Does not cross placenta.
Complications:
Bleeding
HIT
Antibody formation

Answer 4

Heparin

Question 5

Oral
Vitamin K antagonist
4-5 days for therapeutic anticoagulation is achieved.
Complications:
Bleeding
Monitored with INR

Answer 5

Coumadin or Warfarin

Question 6

Direct inhibitors directly binds to target enzyme.
Indirect inhibitors bind to plasma cofactors.
Plasminogen activators converts all plasminogen to plasmin.
Degrades Clot

Answer 6

New Anticoagulant therapy

Question 7

Plasminogen activators converts all plasminogen to plasmin which degrades clot.
Lab Monitoring:
Lytic State decreases fibrinogen which prolongs TT and increases FDPs and decreases plasminogen.
Complications:
Bleeding
Plt dsyfunction

Answer 7

Thrombolytic Therapy

Question 8

Blocks TXA2 synthesis in platelets.
Inhibits COX1
Irreversible

Answer 8

Aspirin

Question 9

Competitive inhibitors of COX1 and COX2.

NOT Irreversible

Answer 9

NSAIDS

Question 10

Plavix

Blocks ADP receptor

Answer 10

ADP receptor antagonists

Question 11

Inhibits phosphodiesterase cAMP levels.

Inhibits platelet activation

Answer 11

Dipyridamole

Question 12

Completely eliminates plt function

Answer 12

Inhibitors of GPIIb/IIIa