Inpatient Peds Flashcards
Barlow Test
First - adducting hip, applying posterior force, pressure on the knee
femoral head OUT of acetabulum
dislocating
Ortolani Test
Abduct the hip, anterior force on femur
reducing
Worrisome Signs of Sacral Dimples
cutaneous signs (hypertrichosis, hemiangioma, etc)
greater than 5mm in diameter
greater than 2.5cm above anus
Ductal Steal
excessive blood flow through pulm circulation –> hypoperfusion of systemic
Chlamydial conjunctivitis presents at age..
5-14d after birth
Chlyamdia PNA presents at what age
4-12 weeks of age
Cow Milk and IDA
Low Fe content of cow mlik
occult GI blood loss w/ CM in 40% of population
inhibition of non-heme iron absorption by casein and calcium
TEN-4
any bruising less than four months
trunks/ears/neck older than 4m
Types of HSV Infection in Neonates
Skin Eye Mucous Membranes
CNS/Meningitis
Disseminated
Phototherapy works by
converting bilirubin to lumirubin (more water soluble)
Bilirubin peaks on what day of life
three (5 if premature)
Phototherapy will decrease bilirubin by what rate…
0.5 /hr
Bilirubin in neonates accumulates in what part of brain
Basal ganglia
Conjugated hyperbili definition
greater than 2 if less than 5
greater than 20%
HSP Diagnosis
EULAR Criteria
have to have purpura/petechiae w predom on lower extremities
+ 1/4: abd pain, arthritis, arthralgia, histo, or renal
Most common cause of hemoptysis in peds
cystic fibrosis
Febrile seizures simple classification
less than 15 minutes
one in 24hr period
generalized, not focal
Monospot/Heterophile Antibody
Good test in older kids (younger kids don’t make Ab, less than 4)
Good when symptoms present at least 5 days, more likely to be positive as time goes on
CBC abnormality w/ EBV
atypical lymphoctes
Mono- keep out of sports for
3 weeks
EBV-NA (nuclear antigen)
positive 1-2 months after infection
Rovsing sign
pain in the right lower quadrant with palpation of the left side
Obturator sign
pain on flexion and internal rotation of the right hip,
which is seen when the inflamed appendix lies in the pelvis and causes irritation of the obturator internus muscle
Iliopsoas Sign
pain on extension of the right hip, which is found in retrocecal appendicitis
Age range for typical intussception
6-36m
Intussception - most common location
ileocecal
Intussception - lead point
peyer patches > meckels, lyphoma
Intussception - imaging
US: target sign
XR: Crescent sign
intussception treatment
air enema
Ladd Bands
connect cecum to abdominal wall, cross duodenum
present in malrotation pts
Malrotation imaging of choice
UGI with contrast
shows corkscrew sign
Cholinergic Poisoning
SLUDGE
Parasympathetic: Salivation, Lacrimation, Urination, Defecation, Gastric Upset, Emesis
Status epilepticus duration
Historically 30 minutes
However, >5 minutes likely to be prolonged and lead to status, so treatment algorithms start here
Otitis Externa - Organisms to cover
Pseudomonas and Staphylcoccus
PID- Short term complications
tubo-ovarian abscess
perihepatitis (Fitz-Hugh-Curtis)
periappendicitis
PID Organisms
- STI- Gonorrhea, Chlamydia
- Ureaplasma, Mycoplasma
- Anaerobes/GI- E coli, Bacteroides, Gardenella, actinomyces, etc…
- Can be due to UTIs
PID Diagnosis
1) Cervical, Adenxal or Uterine Tenderness
and
2) Supportive findings including fever, discharge, +STD, elevated ESR/CRP
PID Oral Treatment
Ceftriaxone + Doxy +/- Flagyl
Lyme Treatment
doxy
amox
cefuroxime
Port Wine Stain
- capillary vascular malformation
- can be associated with Sturge Weber (seizures, glaucoma)
- typically in V1 distribution w/ SWS
Tick paralysis-
mimics GBS
remove tick!
What common peds meds for chronic kids CAN”T be in solution
- levothyroxine
- baclofen
Colic definition
3 hours of crying for 3 days a week for at least 3 weeks
should resolve by 4-6 months
Gianotti Crosti syndrome
papular rash on legs, buttocks, arms
hypersensitivity reaction to prior viral infection
Papular Urticaria
rxn to to insect bites
red papules or vesicles on extremities, can be umbilicated
Edwards Syndrome
Trisomy 18
- rocker bottom feet (vertical talus)
- petite face (small mouth, micrognathia)
- clenched hands, 5th over 4th, 2nd over 3rd
- GI can be malrotation, meckels, omphalocele
Patau Syndrome
Trisomy 13
- micro/anophthalmia, cleft lip and/or palate, and postaxial polydactyly
Apnea Definition
cessation of breathing for 20 seconds
or shorter with bradycardia (HR <100, cyanosis or pallor)
Stridor
high pitch, upper airway obstruction
Wheezing
narrowing of airway
Rhonchi
rattling
larger airway
mucus obstruction
Williams Syndrome
- elfin face, friendly demeanor
- aortic stenosis, arterial stenosis
- hypercalcemia
Hepatomegaly in Newborns
greater than 3.5cm in newborns below costal margin
Hepatomegaly in Children
greater than 2cm in children below right costal margin
Noonan Syndrome
hypertelorism
short stature
webbed neck
pulmonary valve stenosis
Impetigo- organisms
Staph Aurues (MSSA, MRSA) GAS
Adenovirus
commonly pharyngitis and conjunctivitis
TB treatment in children
Under 5 - receive prophylactic treatment
Pneumonia Organisms - Less than age 5
Viral: RSV most common, adeno, humanmeta
Strep Pneumo, H flu > Mycoplasma
Pneumonia Organisms - Age 5 through 18
Mycoplasma > Strep Pneumo, H flu
Blood Cultures in Peds Pneumonia
low clinical utility
- fail to show clinical improvement
- moderate to severe
Effusions size in pediatrics
small - less than 1/4 of thorax
medium - less than 1/2
large - more than 1/2
Peds Pneumonia with Empyema - antibiotics
consider ceftriaxone (resistant s pneumo) + clindamycin or vancomycin (MRSA coverage)
Nitrites vs LE in UAs
nitrite –> specific
LE –> sensitive
Recommendations for Renal Ultrasound in Peds
2-24 months following first febrile UTI
Can use see VUR on renal ultrasounds?
only Grade III-IV
Recommendation for VCUG in Peds
2 or more febrile UTIs 1st febrile UTI w/ - abnormal u/s - 39+ temp + organism other than E coli - Poor growth or HTN
How does H flu get resistance to Amox
Beta lactamase
How does Strep give resistance to Amox
PCN binding proteins
HUS triad
anemia, thrombocytopenia, acute renal failure
McCune Albright Triad
precocious puberty
café-au-late spots
fibrous dysplasia
Cover Test
First eye covered for 1-2 seconds, observe uncovered eye
Cover opposite ever for 1-2 seconds
congenital melanocytic nevi
transformation to melanoma in large CMN, >20cm
grow as children grow
Phytophotodermatitis
rash following citrus exposure and then UV light
Measles- symptoms
cough, coryza, conjunctivitis
Koplik spots
white spots on buccal mucosa, occur before measles rash begins
Measles Complications
- ADEM
- Encephalitis
- Subacute sclerosing panencephalitis
Croup-
parainfluenza
6 months to 3 years
Croup Treatment
Dexamethasone even if mild symptoms
Race epi if stridor at rest
Croup X ray
steeple sign on neck xray, subglottic tracheal narrowing
Racemic Epinephrine
reduce stridor in 30 minutes
lasts no longer than 2 hours
observe for 4 hours
Pleural TB
primary TB pleuritis in kids
reactivation TB pleuritis in adults
obtain pleural biopsy
ASA in Kawasaki Disease
preventing intracoronary thrombosis that could leading to MI in stenotic or aneurysmal coronary artery
Peutz-Jeghers Syndrome
AD
melanocytic macules of lips, buccal mucosa, digits
GI harmartomatous polyps (rectal bleeding, anemia)
DiGeorge Syndrome
CATCH-22 (chromosome 22) C- cardiac abnormalities A- abnormal facies T- Thymic absence or T cell dysfunction C- cleft palate H- hypocalcemia
Raynold Phenomena- Triphasic
1) With vasospasm, the digit exhibits a distinctly demarcated distal pallor coolness (white)
2) cool dusky bluish phase and/or (blue)
3) a bright hyperemic flush (red)
Dermatomyositis MOA
small vessel vasculopathy
Dermatomyositis- muscle symptoms
proximal muscle weakness
proximal muscle weakness=
difficulty getting up out of chair/toilet
climbing stairs
getting on and off the floor
Muscle Enzymes =
CK
LDH
aldolase
AST
Classic KD Symptoms
5 days of fever
4/5 CRASH
Conjunctivitis, Rash, Adenopathy, Strawberry tongue/mucositis, Hands and feet
Incomplete KD Features
sterile pyuria anemia low albumin thrombocytosis elevated ALT leukocytosis or ECHO findings
JIA diagnosis
6 weeks of symptoms
before 16th birthday
Torticollis on Exam
head tilted to one side
chin in opposite direction
Klippel-Feil Syndrome
fusion of cervical vertebra (alantoaxial instability)
short neck
low posterior hair line
Atlantoaxial Rotary Subluxation
children, 6-12 after URI or trauma to neck
head tilts AWAY from SCM muscle
NF1 Skin Lesions
café au lait spots
freckling in axillary or inguinal areas
NF Associated Abnormalities
Lisch Nodules (harmatomas)
Neurofibromas
Optic gliomas
dyshidrotic eczema
acute, pruritic, vesicular lesions
often on hands and feet
What does Bactrim NOT cover?
Streptococcus
Differential Symptoms for Preseptal versus Orbital Cellulitis
symptoms of increased intraorbital pressure
blurred visionopthlamopegia
proptosis
chemosis
Reasons for CT in Orbital Cellulitis
unable to perform exam due to edema
CNS involvement (seizures, AMS)
Clinical deterioration or no improvement in 24-48h
Correction Factor in T1DM
1800 by TDD
how much 1 unit of insulin will drop glucose
Insulin to carbohydrate ratio in T1DM
500 divided by TDD
Hemophilia A
Factor VIII def
X linked
Hemophilia B
Factor ix def
Bilirubin production before the liver
- degrade heme to biliveridin then to unconjugated bilirubin
- binds albumin to arrive to the liver
Bilirubin Metabolism in liver
- conjugated w/ glucuronic acids by BUGT
- secreted into bile ducts
Enterohepatic Circulation =
deconjugated by bacteria or tissue B gluconuridase
Conjugation of Bilirubin in intestine
conjugated to urobilinogen
90% to feces
Jaundice of Face
4-8
Jaundice of Trunk
Upper 5-12
Lower 8-16
Physiological Jaundice can due to
1) increased break down of RBCs
2) low BUGT enzyme activity
3) lack of intestinal flora to metabolize to urobilinogen
Unconjugated Hyperbilirubinemia Differential - Categories
increased production
Reduced uptake
Conjugation Defect
Conjugated Hyperbilirubinemia Differential - categories
biliary obstruction
impaired excretion
intrahepatic
Unconjugated Hyperbili: Increased Production
Physiologic Hemolysis Polycythemia Cephalotoma Infection
Unconjugated Hyperbili: Conjugation Defect
Gilbert
Crigler-Najjar
Physiologic
Hypothyroidism
Unconjugated Hyperbili: Impaired Excretion/Uptake
Prematurity
G6PD Deficiency
Breastfeeding jaundice
inadequate milk intake and dehydration
Breastmilk jaundice
inhibition of BUGT enzyme
increase enterohepatic circulation
Criger Najjar Type I
- absent BUGT
- liver transplant, prolonged phototherapy
- AD
Criger Najjar Type II
- decreased BUGT
- may improve with phenobarbital
Drugs that can cause unconjugated hyperbilirubinemia in neonates
sulfonamides
cephalosporins
aspirin
Biliary Atresia
inflammation on intra and extra hepatic ducts
can have absence of galbladder
Alagille Syndrome
- cholestatic jaundice
- butterfly vertebrae
- peripheral pulmonary stenosis
Pediatric CAP - Blood Culture
obtained when hospitalized w/ moderate or severe illness
complicated illness
empyema
Pediatric CAP - Length of Therapy
Not more than 7 days
Steroids in Pediatric CAP
Only with asthma, otherwise not studied
Recurrent Pneumonia
More than two in one year
More than three in lifetime
Causes of CAP - Less than 3m
GBS, GN enteritis, listeria
HSV, vital
Causes of CAP - Infants
Viruses!
S pneumo > H flu > Mycoplasma
Causes of CAP - Kids Less than 5
Viruses! (viral pneumonitis)
S pneumo > H flu > Moraxella, S aureus, GAS
Causes of CAP - Kids more than 5
S pneumo, Mycoplasma, Chlymadia
CAP Complications
parapneumonic effusion, empyema, lung abscess
Urinary Antigens for CAP in Peds
Not recommended, usually false positive
When to use Ceftriaxone in Peds CAP
- unimmunized
- consideration with empyema
Failure to Thrive Definition
dropping two percentiles
OR
weight less than 3rd percentile
below 5th percentile for weight-for-length
FTT Broad Categories
Inadequate nutritional intake
Malabsorption
Increased metabolic demand
FTT Inadequate nutritional intake
- Neglect
- Emesis/Reflux
- Oromotor dysfunction
FTT Malabsorption
CF
Celiac Disease
Hepatobiliary disease
Food Protein Intolerance
FTT Increased Metabolic Demand
Cardiac, Renal, Endocrine
Congenital Infections
Syndrome
Types of HSV in Neonates
Disseminated Disease
CNS Disease
Skin, Eye, and Mouth Disease
Neonatal Disseminated HSV
- acquired perinatally
- 20% do not have vesicles
- hepatitis, pneumonitis, sepsis, DIC
BRUE Definition
younger than 1 year w/ brief episode associated w/
(1) cyanosis or pallor;
(2) absent, decreased, or irregular breathing;
(3) marked change in tone (hyper- or hypotonia); and
(4) altered level of responsiveness
Low Risk Brue Features
> 60 days
32 GA w/ >45 weeks PCA
less than 1 minute
no other concerning features
BRUE Interventions
Should: educate, often CPR
May: EKG, brief monitoring, pertussis
pRBCs raise the count by
1 for hemoglobin, 3% for hct
platelets raise the count by
20-25k
cryoprecipitate is mainly..
factor VIII and fibrinogen
use for DIC
Kocher Criteria Septic Arthritis
non weight bearing temp >101.3 ESR >40 WBC >12 2 criteria = 40%
Acute Hemolytic Transfusion Reactions
ABO Incompatibility
fever, flank pain, hypotension
Delayed Hemolytic Transfusion Reactions
.minor antigens/non-ABO antigens
fever, hemolysis 7-14 days after
TACO
transfusion associated circulatory overload
respiratory distress within 6 hours of transfusion
TRALI
transfusion related acute lung injury
pulm edema w/in 6 hours of transfusion
more serious- usually fever, hypotension
Febrile Nonhemolytic Transfusion Reaction
temperature increase of 1 degree within 4 hours
due to donor leukocyte cytokines
Bacteremia from transufions
yesrsinia
babeosis
When do we see glucosuria (serum value)
serum 180-200
Ely’s test (peds rheum)
lay flat on table and lift legs
if hips come off table sign of muscle tightness
Thomas Test (peds rheum)
Knees to chest, release one leg and determine whether it relaxes straight or not
Early onset sepsis (neonatal)
before 7 days of life
usually within first 24-72 hours
Late onset sepsis (neonatal)
7 days- 3 months
Late, Late onset sepsis (neonatal)
> 3 months
Antibiotic Coverage for Septic Arthritis in Peds
Cover Staph + Strept
Kingella coverage in preschool children
Rationale for 4 hours Tylenol Level
- absorption has already taken place and now distribution and clearance is occuring
ER Tylenol
Immediate release of 325, release of addition 325 in 4 hours (will need two nomograms)
Osteomyelitis Organisms - Pediatrics
Staph Aureus!!
- Kingella in school age
- GBS, E coli in neonates
- Salmonella in SCD
Serotonin Syndrome - Triad
- altered mental status
- autonomic hyperactivity
- neuromuscular abnormalities (tremor, clonus, hyperreactivity)
AOM less than 6 months
always treat
AOM 6m-2y
treat if bilateral, or severe unilateral
observe if mild and unilateral
AOM >2 y
treat if toxic, otalgia, temp >102.2F
Ocular Clonus
seen with serotonin syndrome!
Treating Pertussis Timeline Pediatrics
within 6 weeks if <1
within 3 weeks if >1
Klippel-Trénaunay syndrome
port wine stain
lymphatic anomalies
variable overgrowth of bones and soft tissue
Theory of D5 in Pediatric Patients with Nausea/Emesis
prevents ketone formation which can worsen nausea/emesis
Post Exposure Prophylaxis (PEP) - Time Course
Within 72 Hours
Nikolsky Sign
Skin sloughs off when touched (cleavage of the epidermis, not dermis)
Happens w/ SSSS
Varicella Lesions
pruritic vesicles on erythematous base
become pustules, crusted papules
Treatment of Staph Scalded Skin Syndrome
Clindamycin (for toxin)
Oxacillin or Cefazolin or Vancomycin
(eh, maybe topical mupirocin)
Staph Scalded Skin Syndrome - Where to look for source
nasopharynx!!
opposite of bullous impetigo where you can culture fluid
Aspirin Overdose Treatment
- activated charcoal
- bicarbonate to alkalinize urine
Aspirin Acid Base Problems
Metabolic Acidosis
Respiratory Alkalosis
Galactosemia
- first days after birth w/ milk or breast milk
- liver dysfxn, anemia, acidosis, reducing substances in urine (galactosuria)
Random Things associated with Galactosemia
- cataracts
- E coli sepsis
Zinc Deficiency
alopecia, skin lesions, diarrhea
TAR syndrome
thrombocytopenia and absent radius
Esophageal damage from ingestion caused by..
alkaline products –> drain cleaner
Infections associated with swimming pools
shigella
Preauricular Pits and further testing
only if other abnormalities are present
Mom’s Blood Type for risk of hemolytic anemia
O blood types
Rh negative
Hemolytic Anemia of Newborn and prior exposures
ABO - new prior pregnancy
RH neg - required prior pregnancy
Varicella and Skin Infections
invasvie GAS
Turner Syndrome
45X
short stature, webbed neck, normal intelligence
streak ovaries/ovarian failure
Congenital vertebral anomalies associated with
renal anomalies!
Caput succedaneum
- localized superficial edema of the scalp most likely due to venous congestion from cervical pressure
- above the periosteum
- cross suture lines
Cephalohematoma
- sub periosteal hemorrhage localized to the surface of 1 cranial bone.
- sharply demarcated boundaries
- underlying linear skull fracture in small percent
Subgaleal hemorrhage
- collection of blood beneath the epicranial aponeurosis and above the periosteum of the skull,
- fluctuant mass that increases in size soon after birth
- vaccum deliveries
When do c diff colonization in infants become equivalent to adults
around 3 years of age
VWF function
actor that allows functional platelets to bind to connective tissue proteins to form a clot
Elevated PT associated with what pathway
extrinsic and common pathways
Elevated PTT associated with what pathway
intrinsic pathways (included VIII)
corneal abrasion treatment
topical antibiotics
double bubble
duodenal atresia
dilated stomach and dudodenum
often w/ scaphoid stomach
duodenal atresia associated with
trisomy 21
vacterl
Potter Sequence
oligohydramnios, renal abnormalities
- pulmonary hypoplasia
- facial abnormalities
- club feet/hip dislocation
Jejunal and Ileal Atresia associated with
caused by impaired vascular flow/vasoconstriction
i.e. cocaine, smoking
heat exhaustion versus heat stroke
mental status changes
Bell’s Palsy Treatment
steroids