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Pharm Unit 4 > Inotropic Drugs > Flashcards

Inotropic Drugs Flashcards

1
Q

Diuretics Class

A

Diuretics

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2
Q

Bisoprolol, carvedilol, sustained release metoprolol Class

A

_-blockers

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3
Q

Digoxin (Lanoxin) Class

A

Cardiac glycoside

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4
Q

Dobutamine (Dobutrex) Class

A

_1 receptor agonist

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5
Q

Milrinone (Primacor) Class

A

Phosphodiesterase IIIa inhibitor

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6
Q

Nesiritide (Natrecor) Class

A

Synthetic BNP

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7
Q

Diuretics MOA

A

Decrease volume and preload

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8
Q

Bisoprolol, carvedilol, sustained release metoprolol MOA

A

Blocks high circulating levels of catecholamines

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9
Q

Digoxin (Lanoxin) MOA

A

Inhibits Na/K/ATPase (increases contractility d/t more Ca); increases vagal activity to heart (reduces SA firing rate, conduction through AV node)

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10
Q

Dobutamine (Dobutrex) MOA

A

Positive inotrope and chronotrope

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11
Q

Milrinone (Primacor) MOA

A

Inhibits cAMP breakdown

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12
Q

Diuretics SE

A

Causes neurohormonal activation

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13
Q

Digoxin (Lanoxin) SE

A

Very narrow therapeutic-toxic window (mostly arrhythmias)

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14
Q

Dobutamine (Dobutrex) SE

A

Quick acting, but can develop tachyphylaxis after 48 hours

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15
Q

Milrinone (Primacor) SE

A

Increased hypotensive and atrial arrhythmia events acutely. 2 month mortality nearly 50% higher than placebo

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16
Q

Diuretics Misc

A

Contraindication in hypovolemic patients

17
Q

Bisoprolol, carvedilol, sustained release metoprolol Misc

A

Should be started at very low dose and slowly ratchet up; do not stop suddenly

18
Q

Digoxin (Lanoxin) Misc

A

Eliminated in kidneys, so dose according to renal function

19
Q

Dobutamine (Dobutrex) Misc

A

No NE release; given IV

20
Q

Milrinone (Primacor) Misc

A

Given IV, depends on renal clearance, no tolerance after 72 hours

21
Q

Nesiritide (Natrecor) Misc

A

Given IV

Pharm Unit 4 (7 decks)

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