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physio-immunology > innate vs. adaptive > Flashcards

innate vs. adaptive Flashcards

1
Q

cells involved - innate

A

leukocytes

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2
Q

cells involved - adaptive

A

lymphocytes

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3
Q

site of action - innate

A

local. confined

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4
Q

site of action - adaptive

A

global, spreading

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5
Q

target - innate

A

non-specific

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6
Q

target - adaptive

A

specific epitope

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7
Q

timing innate

A

early (hrs) “first responder”

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8
Q

timing adaptive

A

late (days) “last resort”

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9
Q

leukocytes

A

neutrophils, basophils, eosinophils, monocytes

macrophages, dendritic and mast cells

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10
Q

lymphocytes

A 
B cells, cytotoxic T, helper T and NK cells
plasma cells (differentiated B cells)
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11
Q

macrophage origin

A

monocytes from bone marrow

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12
Q

NK cell origin

A

bone marrow

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13
Q

mast cell origin

A

unique bone marrow cells

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14
Q

macrophage location

A

outside blood vessels (skin, resp, GI GU tract)

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15
Q

NK cell location

A

blood, extracellular space

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16
Q

mast cell location

A

outside blood vessels in connective tissue

17
Q

macrophage target

A

non-specific response; phagocytosis; cytokines (inflammation)

18
Q

NK cell target

A

virus infected or cancer cells
or
antibody bound foreign cells

19
Q

mast cell target

A

local inflammation to increase blood supply

20
Q

macrophage unique

A

phagocytosis of bacteria with C3b opsonin
MHC Class II protein (APC)
CD4 protein
CCR5 protein

21
Q

NK cell unique

A

unk surface protein to ID virus infected or cancer cells

release interferon gamma

22
Q

mast cell unique

A

large number of vesicles secreting paracrine agents

histamine+chemokines involved in inflammation

23
Q

macrophage receptors

A 
IL2 + 
interferon gamma
C3b (opsonin)
Fc receptor for antibody
TLR for carbs
24
Q

NK cell receptors

A

IL2 +
interferon gamma
autoreceptors
Fc receptor for antibody

25
Q

mast cell receptors

A

IL 2 +

Fc receptors for IgE

26
Q

NK cells innate or adaptive?

A

BOTH
attack tumor or virus infected cells (innate)
attack any cells with IgG
lymphocytes

physio-immunology (6 decks)

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