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physio-immunology > antigen presenting cells > Flashcards

antigen presenting cells Flashcards

1
Q

3 types?

A

macrophage
B cell
Dendritic cell

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2
Q

which one is found in the blood?

A

B cell

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3
Q

which ones are found in the interstitial fluid?

A

macrophage and dendritic cells

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4
Q

B cells are also….

A

effector cells (along with APCs)

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5
Q

macrophages are also…

A

phagocytes

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6
Q

dendritic cells are also…

A

phagocytes

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7
Q

MHC class I proteins found where?

A

ALL cells except RBCs

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8
Q

MHC class II found where?

A

ONLY on surface of macrophages, B cells and dendritic cells (APCs)

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9
Q

MHC class I recognized by….

A

CD8 cells (cytotoxic T cells)

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10
Q

MHC class II recognized by….

A

CD4 cells (helper T cells)

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11
Q

MHC class I source of foreign antigen….

A

endogenous (intracellular pathogens or proteins made by cancer cells)

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12
Q

MHC class II source of foreign antigen….

A

exogenous (phagocytized extracellular pathogens and viruses/cancer cells)

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13
Q

MCH class I display foreign antigen means…

A

i belong to self, but have been invaded or become cancerous! KILL ME

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14
Q

MCH class II display foreign antigen means…

A

i belong to self but have been captured by an alien invader. this is what it looks like. help me mount a defense against it

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15
Q

Dendritic cell origin

A

arise from monocytes (dies in secondary lymphoid tissue unless signaled by activated T cells)

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16
Q

dendritic cell location

A

mature as they reach spleen and lymph nodes

positioned in skin

17
Q

dendritic cell target

A

microbes and other antigens
phagocytosis and antigen presenting via MHC proteins
failure of dendritic cells results in autoimmune disease

18
Q

dendritic cell unique

A

no digestive enzymes
MHC class I and II (APC)
production of IL1,2 and interferon gamma
CD40, CD70, CD 86 proteins

19
Q

dendritic cell receptors

A

IL2+
interferon gamma
autoreceptors
no Rc receptor for antibody

physio-immunology (6 decks)

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