antigen presenting cells Flashcards
(19 cards)
3 types?
macrophage
B cell
Dendritic cell
which one is found in the blood?
B cell
which ones are found in the interstitial fluid?
macrophage and dendritic cells
B cells are also….
effector cells (along with APCs)
macrophages are also…
phagocytes
dendritic cells are also…
phagocytes
MHC class I proteins found where?
ALL cells except RBCs
MHC class II found where?
ONLY on surface of macrophages, B cells and dendritic cells (APCs)
MHC class I recognized by….
CD8 cells (cytotoxic T cells)
MHC class II recognized by….
CD4 cells (helper T cells)
MHC class I source of foreign antigen….
endogenous (intracellular pathogens or proteins made by cancer cells)
MHC class II source of foreign antigen….
exogenous (phagocytized extracellular pathogens and viruses/cancer cells)
MCH class I display foreign antigen means…
i belong to self, but have been invaded or become cancerous! KILL ME
MCH class II display foreign antigen means…
i belong to self but have been captured by an alien invader. this is what it looks like. help me mount a defense against it
Dendritic cell origin
arise from monocytes (dies in secondary lymphoid tissue unless signaled by activated T cells)
dendritic cell location
mature as they reach spleen and lymph nodes
positioned in skin
dendritic cell target
microbes and other antigens
phagocytosis and antigen presenting via MHC proteins
failure of dendritic cells results in autoimmune disease
dendritic cell unique
no digestive enzymes
MHC class I and II (APC)
production of IL1,2 and interferon gamma
CD40, CD70, CD 86 proteins
dendritic cell receptors
IL2+
interferon gamma
autoreceptors
no Rc receptor for antibody
