Innate Lymphoid Cells in Respiratory Allergy & Infection

Question 1

Name the transcription factor needed for ILC1 generation

Answer 1

T–bet

Question 2

Name the transcription factors needed for ILC2 generation

Answer 2

IL-7 signal

RORα and GATA3

Question 3

Name the transcription facotrs needed for ILC 3 generation

Answer 3

RORγt and Ahr

Question 4

Name the factors which activate ILC1

Answer 4

IL-12, IL-15, IL-18

Question 5

Name the factors which activate ILC2

Answer 5

IL-25, IL-33, TSLP

Question 6

Name the factors which activate ILC3

Answer 6

IL-23, IL-1β

Question 7

What do ILC1 produce when activated?

Answer 7

IFN-γ, (TNF-α)

Question 8

What do ILC2 produce when they are activated

Answer 8

IL-4, IL-5, IL-13

Question 9

What do ILC3 produce when activated

Answer 9

IL-17, IL-22

Question 10

Describe the effects of ILC1 signalling

Answer 10

Anti-viral, Intracellular pathogens

Cytotoxic, Macrophage activation, O2 radicals

Question 11

Describe the effects of ILC2 signalling

Answer 11

Anti-parasite, allergic inflammation

Mucus production, vasodilation, tissue repair

Question 12

Describe the effects of ILC3 signalling

Answer 12

Extracellular bacteria

Question 22

What receptor is present and characteristic of Th2/ILC2 cells

Answer 22

CRTH2+

Question 23

Name the type of cell these receptors are found:

CD4

CD8

CD19

CD3

Answer 23

CD4 = Th

CD8 = CTL

CD19 = B cell (BCR)

CD3 = T cell (TCR)