Innate Immunity - Shnyra Flashcards
<p>mediator that causes vasodilation and increased vascular permiability</p>
<p>histamine</p>
<p>Leukocytes include these 4 </p>
<p>1. neutrophils
2. monocytes
3. tissue macrophages
4. eosinophils </p>
monocytes isolated in culture, added IL-4 will result in formation o f
Dendritic Cells
NK cells are categorized as
lymphocytes
first cells to arrive at site of tissue damage
neutrophils
contain cationic granule proteins, fight helminthes (large extracellular parasitic worms) and other multicellular parasites
eosinophils
large granular lymphocytes that kill infected host cells by a cytolytic mediator perforin
NK cells
neutrophils and monyctes enter site through […] except […] (liver, lungs, kidney) where all blood cells enter through capillaries
post-capillary venules
parenchymal tissues
this chemoattractant (produced by mast cells, macrophages) controls migration of neutrophils in to inflammatory sites
IL-8
most important cytokine for very early diapedesis
TNF-alpha
most important cytokine for temp
IL-1
most important cytokine for bringing about Acute Phase Proteins
IL-6
4 molecules regulating chemotaxis
chemokines
C3a
C5a
leukotrienes
chemoattractants for monocytes
macrophage inflammatory protein-1a (MIP-1a)
MIP-1B
only anti-inflammatory cytokine in innate immunity
IL-10
involved in destroying microbes and inflamamtion (macrophage type)
M1
classically activated
involved in tissue repair and controlling inflamamtion
macrophage type
M2
alternatively activated
3 pathways of complement system activatoin
- alternative pathway
- classical pathway
- lectin pathway
most important cytokine for regulating production of APP
IL-6
cytokine critical in activating cytotoxic CTL
released by mature DC
IL-12
