Adaptive Immunity - Shnyra

Question 1

HLA genes are highly […] and have […] co-dominant expression

Answer 1

highly polymorphic

co-dominant expression

Question 2

major barrier for transplantation

Answer 2

polymorphic nature in Class I MHC

Question 3

total no. of genes encoding HLA in each individual

Answer 3

6!

HLA A,B,C x2 from mom and dad

Question 4

low MHC I expression in these 3 cell populations

Answer 4

hepatocytes
kidney
brain

Question 5

specific marker for CTLs

stabilizes TCR interaction with Class I MHC

Answer 5

CD8

Question 6

APCs that can phagocytose

Answer 6

Macrophage

Question 7

extracellular Ag taken up by APC through these 3 ways

Answer 7

phagocytosis
receptor-mediated endocytosis
pinocytosis

Question 8

CD8 binds this domain of MHC I

Answer 8

alpha -3

Question 9

CD4 binds this domain of MHC II

Answer 9

beta-2

Question 10

what is cross-presentation?

Answer 10

Ag taken up from OUTSIDE can be presented by Class I MHC

Question 11

major Ag receptor isotype coexpressed with IgM on surface of most peripheral B cells in humans

Answer 11

IgD

Question 12

surface Ig on BCR

Answer 12

IgM

IgD

Question 13

subunits associated with BCR

Answer 13

Ig-Beta

Ig-alpha

Question 14

identification marker of all T cells

forms complex with TCR

Answer 14

CD3

Question 15

3 invariant domains of TCR complex

Answer 15

epselon-delta [CD3]
gamma-epselon [CD3]
theta-theta

Question 16

major T cell population in epithelial tissues (>50% of T cells)

Answer 16

gamma/delta