Innate immunity: pathogen recognition

Question 1

MAMPs

Answer 1

Microbe associated molecular patterns
-conserved by microbes
-distinct from self
-critical for pathogen’s survival/funct

eg. bact: LPS (gram -ve), flagellins, N-formylated prots, unmeth cpG in DNA
fungi: chitin, beta-glucans, PG
viruses: dsRNA
protozoa: mannose-rich glycans, GPI-linked prots

Question 2

DAMPs

Answer 2

Damage associated molecular patterns
-host components (should be inside cell) released during cell damage

eg. DNA, mitochondrial components, frags of extracellular matrix, uric acid

Question 3

Classes of pathogen recognition receptors (PRRs)

Answer 3

Soluble receptors (eg. mannose-binding lectin)
Membrane receptors (eg. Toll-like receptors)
Cytoplasmic receptors (eg. NOD-like receptors)