Innate Immunity

Question 1

Provides ___ line of defense.

Answer 1

early

Question 2

Does the innate immune system exist before or after infection?

Answer 2

Before infection and responds rapidly

Question 3

What are the innate system cells?

Answer 3

• neutrophil
• eosinophil
• basophil
• mast cell
• monocyte
• macrophage
• dendritic cell
• NK

Question 4

What are the steps in functional responses of phagocytes?

Answer 4

1. CHemokine mediated recruitment of cells to the site of infection
2. Receptor dependent recognition of microbes and activation of phagocytes
3. Formation of phagosome and ingestion of microbes
4. Intracellular destruction of ingested microbes in lysosomes

Question 5

What stimulates production of neutrophils?

Answer 5

G-CSF

Question 6

What cells come from the mononuclear lineage? What stimulates their development?

Answer 6

Blood monocytes and resident tissue macrophages

M-CSF

Question 7

What is the most potent stimulator of T cells?

Answer 7

Dendritic Cells

Question 8

What cells protect against multiccellular organisms such as helminthes?

Answer 8

Mast cells basophils and eosinophils

Question 9

Describe the strategic location of mast cells?

Answer 9

Common at sites in the body that are exposed to the external environment. They lie close to blood vessels so they can regulate their permeability and effector cell recruitment.