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Immunology > Chemokines > Flashcards

Chemokines Flashcards

1
Q

CCL2 original name and major function?

A
  • MCP-1
  • Mixed leukocyte recruitment (monocytes)
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2
Q

CCL19 original name and function?

A
  • MIP-3B
  • T cell and dendritic cell migration into parafollicular zones of lymph nodes
  • Displayed on surface of HEV
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3
Q

CCL21 original name and function?

A
  • SLC
  • T cell and dendritic cell migration into parafollicular zones of lymph nodes
  • Display on surface of HEV
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4
Q

CXCL8 original name and function?

A
  • IL-8
  • Neutrophil recruitment
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5
Q

CCL4 original name and function?

A
  • MIP-1B
  • T cell, dendritic cell, monocyte, and NK recruitment, HIV co receptor
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6
Q

What chemokines are displayed on the surface of HEV and help with T cell and DC migration into parafollicular zone of LN?

A

CCL19 and CCL21

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7
Q

CXCL10 original name and function?

A
  • IP-10
  • Effector T cell recruitment
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8
Q

What chemokine is expressed on HEV to activate integrins and homes Naive B cells to LN’s?

A

CXCL12

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9
Q

In the lymph node B cells migration into the b zone is driven by what chemokine?

A

CXCL13

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10
Q

CXCL13 original name and function?

A
  • BCA-1
  • B cell migration into follicles and T follicular helper cell migration into follicles
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11
Q

CXCL12 original name and function?

A
  • SDF-1aB
  • Homing naive B cells to LNs
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12
Q

Where are P-selectins (CD62P) found and what is the ligand?

A
  • Found on the endothelium activated by thrombin or histamine
  • Ligand is Sialyl Lewis X antigen on PSGL-1 and other glycoproteins. Expressed on neutrophils monocytes and t cells
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13
Q

Where are E-selectins found and what is lignand?

A
  • Endothelium activated by cytokines (TNF, IL-1)
  • Sialyl Lewis X antigen (CLA-1) on glycoproteins, neutrophils monocytes and T cells
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14
Q

Where are L selectins found and ligands?

A
  • On all leukocytes- neutorphils, monocytes, T cells, B cells
  • Ligan is Sialyl Lewis X/ **PNAd on HEV
  • Lymphocytes without L selectin cant enter peripheral nodes
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15
Q

LFA-1 ligand?

A
  • Lymphocyte Function associated antigen 1
  • ligand is ICAM-1 and ICAM-2 expressed on endothelium
  • LFA-1 found on neutrohils, monocytes, T cells and B cells
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16
Q

VLA-4?

A
  • Very Late Antigen 4
  • VCAM-1 expressed on the endothelium is the ligand
  • VLA-4 found on Monocytes T cells
17
Q

Mac-1?

A
  • ICAM-1 and ICAM-2 expressed on endothelium is the ligand
  • Macrophage-1 antigen aka CR3
  • Mac-1 is found on neutrophils monocytes and DC’s
18
Q

Alpha4Beta7 Integrin?

A
  • Ligand is VCAM-1 and MadCAM-1 expressed in the endothelium of gut and GALT
  • A4B7 found on monocytes t cells b cells for the gut
19
Q

IL-1?

A
  • Promotoes maturation of B and T cell
  • Causes inflammation fever and synthesis of acute phase proteins
20
Q

IL-1B

A
  • Pro inflammatory cytokine secretd from DC’s in response to DAMP’s binging CD91
  • activates leukocytes
21
Q

IL-2

A
  • Promotes T cell maturation
  • Stimulates clonal expansion of Ag activated T cells
  • Starvation of IL2 results in intrinsic pathway of apoptosis
22
Q

IL-4

A
  • Activates Th2 cells
  • induces differentiation of macrophages
  • Co activator of mast cells with IgE
  • Stimulates IgE production
23
Q

IL-5?

A
  • Activates eosinophils to release granules in response to Helminths
  • Made by Th2 cells
24
Q

IL-6

A
  • Promotes B and T maturation
  • Activates Th cells
  • Primary regulator of acute phase proteins
25
Q

IL-10

A
  • Anti inflammatory
  • Inhibits cytokine/chemo expression
  • Reduces MHC II expression
26
Q

IL-12

A
  • Produced by DC’s
  • Control CMI by T cell stimulation
  • NK respond to IL-12
27
Q

IL-18

A

Drives inflammation

28
Q

CRP and SAP?

A
  • Induced by IL-6 and IL-1 to activate complement by binding C1q and initiating classical pathway
29
Q

IFN-a and IFN-B?

A
  • Type I IFN’s secreted in response to infected cells to enhance CTL killing
  • Activates JAK-STAT pathway to protect neighboring cells
  • Produced by pDC’s
30
Q

IFN-y

A
  • Most potent activator of phagocytosis in response to IL-12
  • Activates macrophages
  • Produced by NK cells
  • Stimulates MHC II expression on APC’s
31
Q

HMGB1

A
  • Released during necrosis activates NF-kB path
  • Receptor is RAGE
32
Q

HSP?

A

binds to CD91 and is released from necrotic cells to induce NF-kB path and release inflammatory cytokines TNFa and IL-1B

33
Q

What are the extracellular TLR?

A
  • 1
  • 2
  • 4
  • 5
34
Q

Intracellular TLR?

A
  • 3
  • 7
  • 8
  • 9
35
Q

NLR?

A
  • ilgand is PAMP and DAMP
  • forms inflammasome
  • activates caspase 1 to cleave IL-1b and IL-18 to active form
36
Q
A

Immunology (12 decks)

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