Innate immunity Flashcards
1
Q
What are Fc receptors?
A
- Present on phagocytes
- Bind to the constant region of antibodies
2
Q
What are interferons?
A
- Inhibit viral replication
- Secreted by: lympocytes, macrophages, virally infected cells
3
Q
What do interferons do?
A
1) Signals neighboring UNINFECTED cells to destroy RNA and reduce protein synthesis
2) Signals neighbouring INFECETED cells to undergo apoptosis
3) Activates immune cells
4
Q
What are PRRs?
A
- TLR
- NLR
- CLR
- RLR (in cytosol)
5
Q
How are natural killer cells activated?
A
By interferons
6
Q
How do natural killer cells kill cells?
A
- Release granules containing
- Perforin which punctures holes in the cell
- AND granzyme which activate caspase (a protease)
7
Q
What cells contribute to immunological suvaillance?
A
Natural killer cells
Dendritic cells
8
Q
What do dendritic cells do?
A
- Activated by PRRs
- Cleave proteins into peptdie fragments
- Migrate to lymph node and activated T cells
9
Q
What do defensins do?
A
- Ampipathic
- Bind to pathogen bilayer and form pores
10
Q
What forms the MAC?
A
C3b from C3 in the compliment system
