Innate Immunity Flashcards
Which cytokines play significant roles in linking innate immunity (nonspecific), and adaptive/acquired immunity (specific)?
IL-1, IL-6, and TNFa
The endpoint in the nucleus is that TLY activation results in two transcription factors being activated… what are they?
IRF-3 and NF-kappaB
What does IRF-3 stimulate?
production of antiviral type 1 interferons such as IFN alpha/beta
What do antiviral type 2 interferons do?
they are cytokines that block viral replication - which is imp for when a virus infects you
What does NF-kappaB do?
responsible for genes that activate the cells in the blood vessel
-promotes expression of pro-inflammatory cytokines
endothelial adhesion molecules
-chemokines
What are examples of PRRs?
- toll-like receptors (TLR)-> LPS
- Mannose receptors -> bacterial glycoprotein
- N-formyl methionine receptor-> N-formyl methionine on microbes
What do mast cells do?
they mediate vasodilation and vascular constriction
-they facilitate delivery of blood, plasma and cells to injured area
What do macrophage and dendritic cells do?
they produce proinflammatory cytokines such as TNF and IL-1
what is the ligand in endothelial cells?
e selectin
what is the ligand in leukocytes
selectin ligand
what is the receptor in the endothelial cells
ICAM1
what is the leukocytes receptor
LFA1
pus in a case stem….think what?
neutrophils and innate immunity
NK cells respond to what? then what?
IL-12 and then secrete IFN-g
What are the 3 pathways for complement?
Alternative-> Innate-> microbe
Classical->Adaptive->Antibody
Lectin->Innate->Mannose binding lectin
What are the products in the early steps of complement?
C3b binds CR1->phagocytosis
What are the products in the late steps?
MAC
C5a->most potent anaphylotoxin
