Innate Immunity Flashcards
1
Q
What is a complement system?
A
bacterial components activate a cascade of proteolytic reactions leading to the coating of bacteria with complement fragments.
2
Q
What are the 3 complement system pathways?
A
Classical
Lectin
Alternative
3
Q
What are the classical compliment pathway components?
A
- antibody dependent
- C1q, C1r, C1s,C2, C4 complexes
- C3 (C4b2a) generation
- activation of C5
- lytic attack pathway
4
Q
What are the lectin pathway components?
A
- antibody independent
- serum lectin binds sugars
- MASP’s, C4, C2
- C3 (C4b2a) generation
- activation of C5
- lytic attack pathway
5
Q
What are the alternative pathway components?
A
- antibody independent
- pathogens or apoptotic tissue
- C3b, FB, FD, P
- C3 (C4b2a) generation
- activation of C5
- lytic attack pathway
