Innate Immunity Flashcards
Most prevalent leukocyte
Neutrophil
Granulocytes
Neutrophil
eosinophil
basophil
circulating agranulocytes
Monocytes
lymphocytes
After entering tissue, monocyte turn into:
macrophages
The principal leukocytes that mediate acute inflammation:
Neutrophils
monocytes (macrophages)
Immature neutrophils exhibit:
chromatin appears as single band instead of 3-5 clumps
highly phagocytic
neutrophil
two ways neutrophils kill
reactive oxygen species (ROS) - toxin
protease and other enzymes
Neutrophils extrude DNA when they encounter large number os pathogens. This is known as:
Neutrophil extracellular traps (NET)
rare, circulate in blood stream, non-phagocytic granulocytes
Basophil
Non-phagocytic granulocyte, resides in tissues
mast cells
contain histamine
mast cells and basophils
Kills larger targets such as paracytes
eosinophil
phagocytic granulocyte
eosinophil
participates in allergic responses and airway hyperresponsiveness
eosinophils
macrophage in the liver
kupffer cell
the movement of a cell toward or away from a chemical stimulus
chemotaxis
phagocytes use what to move toward a damaged cell?
pseudopods
Most critical cell for communication between innate and adaptive immune systems
Dendritic cells
antibodies or complement proteins from the host coat the microbe surface
opsonization
Triggers that active innate immunity
Danger-associated molecular patterns
- tissue damage
- Cellular death
- cellular stress
When tissue damage occurs without pathogen invasion (sprained ankle, etc)
sterile inflammation
subset of pattern recognition receptors (PRR) that mediate pathogen recognition in the innate immune system.
Toll-like receptors
Recognize components of bacterial, yeast, or parasite cell membranes
Toll-like receptors (TCR)
