Injury and Inflammation

Question 1

What organ is this, what sort of injury is this and how can you tell

Answer 1

Liver - Reversible injury
Cell swelling, plasma outpouchings (blebs)
Organelle swelling
Lipid vacuoles in the cytoplasm (only if organ metabolises fat, so liver and myocardium)

Question 2

What organ, what sort of injury and how can you tell

Answer 2

Liver - Irreversible injury (on right, left side is normal)
Cytoplasmic eosinophilia (loss of RNA)
Moth eaten cytoplasm
Nuclei are shrunken, pale, fragmented

Question 3

What organ, what sort of inflammation is this and how can you tell

Answer 3

Lung - acute inflammation
Inflammatory exudate containing fibrinogen and neutrophils
Dilated blood vessels
Tissue necrosis
Apoptotic debris

Question 4

What type of inflammation, how can you tell and identify A+B

Answer 4

Chronic inflammation (in pericardium)
Loss of architecture
Infiltration by macrophages, lymphocytes and plasma cells
Repair by granulation tissue (showing organisation)
A - Capillaries and fibroblasts
B - Collagen

Question 5

What do these images show, how can you tell?

Answer 5

Granulation tissue
Blood vessels, oedema, loose ECM containing the occasional inflammatory cell
Trichome (bottom image) shows collagen stained blue

Question 6

What is shown in this image, what cells are present, what can cause this?

Answer 6

Granuloma (from TB patient)
Chronic inflammation walls off persisten pathogens
Cells present - lymphocytes, multinucelated giant cells, epithelioid cells
Causes - TB/syphilis/Toxoplasmosa/helminths, sarcoidosis, Crohn’s disease

Question 7

What is being shown in this image, comment on each image

Answer 7

Healing of a skin ulcer (ulcer = loss of epithelium)
A - pressure ulcer of the skin (common in diabetics)
B - skin ulcer, large gap between edge of lesions
C - a thin layer of epidermal re-epithelialisation, extensive granulation tissue formation in the dermis
D - Continuing re-epithelialisation of epidermis, wound contraction