Injury And Healing Flashcards
What are the three mechanisms of a fracture?
Stress, trauma and pathological
What are the two types of trauma fractures?
High energy and low energy
What is meant by a stress fracture?
When there is abnormal stress placed on normal bone
Which bones do stress fractures normally occur on?
Weight bearing bones
What activities are stress fractures related to.
Athletes, occupational, military
What is an insufficiency fracture?
When the bone may have been thinned or weakened, so is insufficiently strong
link between stress fractures and complete fractures
Many stress fractures leads to the risk of a complete fracture
Describe the sequence of events that can result in a stress fracture?
Overuse of the bone
Stress on bone > bones capacity to remodel
Bone weakens
Stress fracture
What factors can cause bone weakening?
Disordered eating, osteoporosis, amenorrhea
What is meant by a pathological fracture?
Where NORMAL stresses are exerted in ABNORMAL bone
What are some causes of abnormal bone seen in pathological fractures? POMOVO - 6
Pagets
Osteogenesis Imperfecta
Malignancy
Osteomyelitis
Vitamin D deficiency
Osteoporosis
What is osteomyelitis?
Inflammation or swelling that occurs in the bone
What happens when osteoclast activity > osteoblast activity?
Bone micro architecture is disrupted
what happens in osteomalacia?
reduction in bone mineralisation - softening of bones
what happens in osteoporosis
weakening of bones - brittle bone
Why are women more prone to osteoporosis
oestrogen slows down bone loss and improves retention of calcium
How is osteoporosis measure?
By having a bone density that is more then 2.5x standard deviations away from the mean
Is osteoporosis more common in males or females?
Females
What is senile osteoporosis?
Primary osteoporosis that is linked to age
what is osteopenia?
when the protein and mineral content in bone tissue is reduced, before development into osteoperosis
What is secondary osteoporosis?
Osteoporosis that occurs in any age
what type of trauma fractures are found in osteopenia and osteoporosis
low energy trauma
What are three causes of secondary osteoporosis?
Hypogonadism
Glucocorticoid excess
Alcoholism
What type of fractures is secondary osteoporosis associated with?
Hip, spine and wrist fractures = fragility fractures
What minerals does vitamin D help absorb?
Calcium, magnesium and phosphate
How is vitamin D made?
Synthesized from the sun
What happens if you have inadequate calcium or phosphate?
Results in a defect in Osteoid matrix mineralization
What condition does vitamin D deficiency result in for children?
Rickets
What condition does vitamin D deficiency result in for adults?
Osteomalacia
What is reduced in osteogenesis imperfecta?
Type 1 collagen
Why are collagen levels lower in osteogenesis perfecto patients? - 2
1 - Decreased secretion
2 - Production of abnormal collagen
What does osteogenesis imperfecta impact? - 4
Bones
Hearing
Heart
Sight
Blue sclera is a symptom of what condition?
Osteogenesis imperfecta
What is Paget’s disease?
Excessive bone breakdown and disorganized remodeling which leads to deformity
What are the four stages of Paget’s disease?
- Osteoclastic activity
- Mixed osteoclastic-osteoblastic activity
- Osteoblastic activity
- Malignant degeneration
what are lytic cancers in bones
bone eating/breakdown cancers
what are blastic cancers in bones?
endures bone growth
Which cancers are blastic? - 2
Prostate cancer and breast cancer
Which cancer are lytic (bone eating)? - 3
Kidney, thyroid, lung and breast
What are the four primary bone cancers? - 4
Osteosarcoma
Chondrocarcoma
Ewing sarcoma
Lymphoma
What are secondary bone cancers?
When cancers which originated in other tissues metastasize to the bone
What are the two types of fractures which affect the soft tissue integrity?
Open and close
What is a closed fracture?
Fractured under the skin
What is an open fracture?
One that pokes through the skin
What are the two types of fractures which involve the movement to the bone?
Displaced and undisplaced
What is an undisplaced fracture?
fracture where bones are not out of alignment
What is a displaced fracture?
A fracture where bones are no longer in their correct alignment positions
What are the three fractures associated with bony fragments?
Green stick, simple and multi fragmentary
What is a green stick fracture?
When the bone fragments are bent
What is a multi fragmentary fracture?
When there are many fractures along the same bone resu,ting in many bone fragments
What are the 4 stages of general tissue healing?
Bleeding
Inflammation
New tissue formation
Remodelling