Inhibitors of RAA Flashcards
ACE inhibitors
MOA
decrease ATII formation
What is the consequence of dec in ATII formation
dec aldo secretion dec ATII-induced vasoconstriction dec NE release -- dec vasoconstriction dec remodeling inc BK/PG
ACEI effects
dec TPR, sodium/fluid retention, BP
inc HR
ACE-I examples
Enalapril
Lisinopril
What are most ACEI
prodrugs
Which two ACEI are not prodrugs
Captopril
Lisinopril
Which ACEI are HM and RE?
Fosinopril
Therapeutic use ACEI
Htn
CHF
Post MI
Diabetic nephropathy
ADR for ACE-I
Fetopathic potential Cough Hyperkalemia Hypotension Hypersensitivity
CI - ACEI
Pregnancy
Hyperkalemia - renal disease, k-sparing diuretics, k-supplements
Hypersensitivity
AT receptor antagonist
Losartan
Valsartan
MOA AT-RA
competitive antagonism at AT-receptors
are effects of AT-RA similar to ACEI?
yes
ADR of AT-RA
Fetopathic potential
Hyperkalemia
Hypotension
Hypersenstivity
NO cough***
CI - AT-RA
similar to ACE-I
renin inhibitor
aliskiren
What does inhibition of renin cause
dec ATI and ATII
Therapeutic use of Renin inhibitor
Htn
is there more or less cough with renin inhibitor in comparison to ACE-I
less
Vasodilators and RAA system inhibitors are used for
Htn
Angina/Ischemia
CHF
