Inhibitors of RAA Flashcards
1
Q
ACE inhibitors
MOA
A
decrease ATII formation
2
Q
What is the consequence of dec in ATII formation
A
dec aldo secretion dec ATII-induced vasoconstriction dec NE release -- dec vasoconstriction dec remodeling inc BK/PG
3
Q
ACEI effects
A
dec TPR, sodium/fluid retention, BP
inc HR
4
Q
ACE-I examples
A
Enalapril
Lisinopril
5
Q
What are most ACEI
A
prodrugs
6
Q
Which two ACEI are not prodrugs
A
Captopril
Lisinopril
7
Q
Which ACEI are HM and RE?
A
Fosinopril
8
Q
Therapeutic use ACEI
A
Htn
CHF
Post MI
Diabetic nephropathy
9
Q
ADR for ACE-I
A
Fetopathic potential Cough Hyperkalemia Hypotension Hypersensitivity
10
Q
CI - ACEI
A
Pregnancy
Hyperkalemia - renal disease, k-sparing diuretics, k-supplements
Hypersensitivity
11
Q
AT receptor antagonist
A
Losartan
Valsartan
12
Q
MOA AT-RA
A
competitive antagonism at AT-receptors
13
Q
are effects of AT-RA similar to ACEI?
A
yes
14
Q
ADR of AT-RA
A
Fetopathic potential
Hyperkalemia
Hypotension
Hypersenstivity
NO cough***
15
Q
CI - AT-RA
A
similar to ACE-I
