Inhibitors Of ETC

Question 1

CoQ collects reducing equivalents from which reactions

Answer 1

1. NADH via complex 1
2. Succinate dehydrogenase (FADH2) via complex 2
3. Acyl- CoA dehydrogenase (FADH2) through a series of electron carriers
4. Glycerol 3 phosphate dehydrogenase shuttle (FADH2)

Question 2

Respiratory inhibitors

Answer 2

Rotenone and barbiturates btw NADH and Q
Antimycin A btw Q and cyt. C
CN- and CO btw cyt. C and O2

Question 3

Two components of proton motive force

Answer 3

1. Chemical potential energy- Due to difference in concentration of H plus
2. Electrical potential energy: Due to the separation of charges

Question 4

Where is energy stored in ETC

Answer 4

In electrical chemical gradient (proton motive force)

Question 5

Inhibitor of electron transfer effect on etc and atp synthesis

Answer 5

Will inhibit both the oxygen consumption and ATP synthesis

Question 6

Venturicidin and oligomycin

Answer 6

Block, ATP synthase, and the protons that are pumped to remain in the inner mitochondrial membrane and build up to a very high concentration so the energy required to pump protons against the gradient, will eventually exceed the energy available from NADH oxidation and proton, until they can no longer brought the protons, and Kanell longer perform electron transport

Question 7

DNP

Answer 7

Is a chemical an coupler and allows protons in the inter-membrane space to cross back into the matrix without coming through ATP synthase in this case ATP production seizes, but electron transport continues to donate true fennel late, and I own a pics of a proton to form the NBH at transported across in a mitochondrial membrane, it will released 8+ in the matrix forming a And then DNB minus will cross back into the intermittent membrane space the proton gradient is collapsed in the synthesis of ATP stops