Inhibitors

Question 1

What are the 2 types of inhibitors?

Answer 1

-competitive + non-competitive

Question 2

What are competitive inhibitors?

Answer 2

-have similar shape to substrate molecule and compete with the substrate for the active site
-fit in = enzyme inhibitor complex = prevents substrates entering

Question 3

What are non-competitive inhibitors?

Answer 3

-bind to the enzyme at an allosteric site - alters the shape of the active site
-prevents substrate from binding to it
-disrupts the structure

Question 4

The reaction rate of competitive inhibitors

Answer 4

-increase in inhibitors - increasing the substrate concentration
-can increase the rate of reaction
-more likely to collide with active site

Question 5

The reaction rate of non-competitive inhibitors

Answer 5

-increase substrate concentration- can’t increase rate of reaction
-as shape of active site remains changed
-so complexes are unable to form

Question 6

Reversible + non-reversible

Answer 6

-2 types of inhibitors

Question 7

What are irreversible inhibitors?

Answer 7

-inhibitors can form covalent bonds with enzymes = inhibiting them permanently
-results in complete inactivation of the enzyme
-can be dangerous as biological reaction will be stopped

Question 8

What are reversible inhibitors?

Answer 8

-bind to active site through H bonds + weak ionic interactions = dont bind permanently
-act as regulators in metabolic pathways