Inhibition of DNA Replication/Transcription

Question 0

Norfloxacin

Answer 0

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 1

Ciprofloxacin

Answer 1

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 2

Levofloxacin

Answer 2

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 3

Ofloxacin

Answer 3

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 4

Sparfloxacin

Answer 4

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 5

Moxifloxacin

Answer 5

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 6

Gatifloxacin

Answer 6

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 7

Enoxacin

Answer 7

• Bactericidal Fluoroquinolones
• MOA: Inhibits DNA gyrase (topoisomerase II)
• Cannot take w/ antacids
• Use: gram - of urinary or GI tracts
  
  1. Pseudomonas
  2. Neisseria
  3. Some gram +
• Toxicity: GI upset, Super infections, skin rashes, headache, dizzy
  
  1. contraindicated in pregnancy and children b/c tendon damage
  2. Tendonitis/rupture in adults
  3. leg cramps and myalgias in kids
• Resistance: chromosome encoded mutation in DNA gyrase

Question 8

Metronidazole

Answer 8

• Bactericidal antiprotozoal
• MOA: free radical toxic metabolites in bacteria that damages DNA
• Use: Giardia, Entamoeba, Trichomonas, Gardnerella vaginalis, Anaerobes (Bacteroides, C. diff)
  
  1. Used w. bismuth & amoxacilin for 3x therapy for H. pylori
• Toxicity: Disulfram-like reaction w/ alcohol