inhibition of cell wall synthesis

Question 1

Which type of organism does benzylpenicillin act on?

Answer 1

Mostly gram positive (eg. S.pneumoniae - given IV/S.pyogenes) and also gram negative N.meningitidis

Question 2

Streptococci, Enterococci (gram positive) and also gram negative infections can be treated with?

Answer 2

Amoxicillan and ampicillan

Question 3

What is the risk of using co-amoxiclav?

Answer 3

Risk of C.diff infection. Used against gram negatives and has an extended spectrum to cover B-lactamase producing coliforms.

Question 4

What is the first choice of treatment for Staphylococcal infections?

Answer 4

Flucloxacillan

Question 5

Which B-lactams have the widest broad spectrum activity?

Answer 5

Imipenem and meropenem

Question 6

Which organisms is piperacillan effective against?

Answer 6

Broad spectrum with extended gram negative cover and anti-anaerobic activity

Question 7

Which 3 sub-classes of antibiotic inhibit cell wall synthesis?

Answer 7

B-lactams, cephalosporins and glycopeptides

Question 8

What are the 2 most commonly used glycopeptides?

Answer 8

Vancomycin and teicoplanin

Question 9

What is vancomycin used to treat?

Answer 9

Orally - C.diff. IV - MRSA. Only effective against gram positive organisms.

Question 10

Is teicoplanin effective against gram positive or gram negative organisms?

Answer 10

Gram positive

Question 11

Are cephalosporins effective against gram positive or gram negative organisms?

Answer 11

Both