Inhalant Anesthetics

Question 1

which drug is the most potent cerebral vasodilator?

Answer 1

halothane

-increase intracranial pressure

Question 2

which drug is the most arrhythmogenic?

Answer 2

halothane

Question 3

how is halothane excreted?

Answer 3

60-8-% in the lungs and the rest in the liver/kidney

Question 4

T/F: halothane cause an increase in hepatic blood flow

Answer 4

False. Most inhalant anesthetics cause a decrease in hepatic blood flow

Question 5

Which drug can result in the build up of thymol?

Answer 5

Halothane

-be sure to clean vaporizer

Question 6

what is the blood/gas coefficient of halothane?what does that mean?

Answer 6

• 2.4

- has a slow induction and slow recovery

Question 7

which inhalant anesthetic is most commonly used?

Answer 7

isoflurane and sevoflurane

Question 8

which inhalant anesthetic is rarely used?

Answer 8

halothane

Question 9

what is the blood gas coefficient of isoflurane?

Answer 9

1. 4

- faster onset, recovery, réponse to dose adjustments in comparison to halothane

Question 10

T/F: isoflurane metabolizes in the lungs and liver.

Answer 10

False

NO METABOLISM

Question 11

T/F: isoflurane is an anticonvulsant and maintains cerebral vascular auto regulation

Answer 11

True

Question 12

How are the pharmokinetics in isoflurane in comparison to halothane?

Answer 12

less cardiac depression, less vasodilation, less hepatic blood flow

MORE ENHANCEMENT OF NEUROMUSCULAR BLOCKERS

Question 13

what is blood gas coefficient for sevoflurane?

Answer 13

.65

- less than isoflurane so it is faster

Question 14

T/F: there is minimal metabolism with sevoflurane

Answer 14

true

- 2-3%

Question 15

T/F: the is more cerebral vasodilation in sevoflurane than there is in isoflurane

Answer 15

false

Question 16

Which drug reacts with soda lime CO2 absorbent that auses the formation of Compound A (NEPHROTOXIN)

Answer 16

sevoflurane

Question 17

which drug requires a special vaporizer?

Answer 17

desflurane

Question 18

which drug has the lowest blood gas coefficient

Answer 18

desflurane

Question 19

Explain the metabolism of desflurane

Answer 19

NO METABOLISM

- just like isoflurane

Question 20

Compare isoflurane and desflurane pharmokinetics

Answer 20

• similar effects in cardio, NMBs, MM relaxation, Liver blood flow
• desflurane has more respiratory depression and does not substantially lower renal blood flow

Question 21

which drug is known as laughing gas?

Answer 21

Nitrous Oxide

hahahahahahahahahahahahaha!

Question 22

what is the blood gas coefficient of nitrous oxide?

Answer 22

.47

super fast

Question 23

T/F: Nitrous oxide has a very high MAC and is a very potent inhaler

Answer 23

False. Is it not a potent inhaler but yes has a very high MAC

Question 24

what is the only inhaler that causes analgesia?

Answer 24

nitrous oxide

Question 25

T/F: you would not need an anesthetic adjuvant with nitrous oxide

Answer 25

false you definitely would

Question 26

explain the pharmokinetics of nitrous oxide

Answer 26

minimal resp, cardio, liver, and renal effects

Question 27

T/F: nitrous oxide increase cerebral blood flow and ICP

Answer 27

true

Question 28

T/F: nitrous oxide can build up in circle systems and diffuse into air filled spaces and explained the gas volume

Answer 28

True

Question 29

what is the fink effect? which drug?

Answer 29

Nitrous oxide
- diffusion hypoxia. not enough O2 is being taken in during recovery because of displacement of other gases when nitrous oxide occupies the space within the alveolus.

-give 100% O2 during recovery

Question 30

what is the second gas effect?

Answer 30

because nitrous oxide is highly soluble, a higher volume of gas is moving into the alveolus to equilibrate with the blood

faster induction is seen clinically