Inflammatory skin disorders Flashcards

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1
Q

name a condition with a purplish purpuric lesions?

A

lichen planus

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2
Q

name the three histological features?

A

basal cell liquidifed degeneration
lymyphocyte infilteration
thickening of the granular layer

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3
Q

what age bracket do the majority occur In?

A

2/3 in 30-60 year old

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4
Q

m to f ratio?

A

equal

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5
Q

what is it cause?

A

unknown/unclear

igM found in the dermoepithelial junctions

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6
Q

where does it usually start?

A

limbs - forearms and wrists, thighs and shins,
other areas genitals, pales/soles of feet
can spread but usually localised

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7
Q

does it clear itself ?

A

yes by 9 months often leaves pigmentation or becomes hypertrophic
15% will still have some 1.5 years later

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8
Q

does it comeback?

A

15-20% have recurrence

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9
Q

treatment

A

self limiting but can give
anti histamines
steroids-prednisolone
UV photherapy

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10
Q

what percentage of the population is affected by psoriasis?

A

2%

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11
Q

what age group does it commonly affect?

A

30s, teens, over 60s

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12
Q

description?

A

salmon pink crusty flaky patches with silvery scales

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13
Q

what are the five types?

A
gutatte 
flexoral
palmoplantar pustular 
classical
erythrodemic
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14
Q

describe the key features of guttate

A

usually in childhood
associated with post step. tonsillitis
multiple erythematous and scaly macules

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15
Q

palmoplantar pustular?

A

yellow-brownish plaques on soles and palms

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16
Q

classical

A

auspitz sign- bleeding with removal of scale
extensors commonly affected
itchy
well circumscribed silvery scaled

17
Q

flexoral

A

seen in women, HIV+ elderly
in submammalary, axillary, anogenital region
not scaly, just erythematous

18
Q

erythodemic

A

emergency
treat with methotrexate
only scales
acute onset

19
Q

name the four key features associated with nails

A

oncholysis
pitting
oil drops
subungual hyperkeratosis

20
Q

triggers

A
stress
infection 
drugs - lithium, beta blockers, ACEi
trauma - koebner phenomen
smoking 
alcohol
sun exposure 
(element of genetic predisposition)
21
Q

treatment -1st line

A

dithranol

22
Q

2nd line

5

A
UVB therapy
Vit D 
salicylic acid 
tar 
topic steroids
23
Q

3rd line

A

retinoids

24
Q

name an example of a retinoid?

A

acitretin

25
Q

what is geokerman regime

A

UVB + tar

26
Q

ingram regime?

A

geokerman reigm + dithranol

27
Q

how does dithranol work?

A

reduce cell proliferation