Inflammatory/ neoplasia Bone dz Flashcards
Osteitis
Inflammation of bone
-general term
Periostitis
Inflammation of periosteum
Osteomyelitis
Inflammation of medullary cavity
-most common inflammatory condition
Bone sequestrum
- Fragment of dead bone
- surrounded by inflammatory cells and exudate
(chronicity –> involucrum)
Involucrum
Sequestrum surrounded by DENSE RING of reactive bone
Infectious Osteomyelitis
- most common in neonatal farm animals
- hematogenous distribution
-Fungi are more common in domestic animals
Viral osteomyelitis
-Viruses w/ true inflammation
- Hog cholera
- Canine hepatits virus
–> endothelial damage –> metaphyseal hemorrhage
Viral osteomyelitis
-Virus w/o true infection
- Distemper virus
- Osteoclast infection –> growth retardation lattice (disrupt growth plate modeling)
- FeLV
- infection/necrosis of hematopoietic cells –> myelosclerosis
Metaphyseal Osteopathy
Osteomyelitis of trabecular bone w/ periosteal bone formation
- Multiple swollen joints & fever
- Young, Lg breed dogs
Oblasts die & matrix reduces –> trabeculae collapse –> (Bilateral) parallel fracture at growth plate
Rads of Metaphyseal osteopathy
Alternatig dense and lucent areas parallel to physis
BILATERAL
Aseptic necrosis of bone
- Retain growth plate
- lack mineralization
Legg Calve Perthes Dz
Asceptic necrosis of femoral head –> collapse of articular cartilage
–Miniature dogs
Clincal signs of Bone neoplasias
- lameness
- pain
- hypercalcemia
- increase ALP
- fractures
Tumors w/ abundant fibrous stroma –>
NEW bone formation
Tumors w/ little stroma (lymphoma) –> no bone/lysis
Hypertrophic osteopathy
Progressive, bilateral periosteal bone formation of diaphysis of distal limbs
Always have some kind of space occupying mass
Osteochondromas
*NOT a neoplasm
Multiple masses adj to physes of long bones & ribs
*possible malignant transformation
-Cat –more common in adults and in flat bones
Fibrous dysplasia
Multifocal lytic intraosseous lesions
-young animals
- Pre-existing bone exchanged for well-diff fibrous tissue & woven bone
- *no Oblast
Bony cysts
Sequelae of:
- osteochondrosis
- degenerative joint dz
- ischemia
- malformation
Name 6 Primary neoplasms of bone
- Ossifying fibromas
- Chondromas
- Chondrosarcomas
- Osteomas
- Osteosarcomas
- Multilobular tumor of bone
Ossifying fibroma
- Benign
- maxilla/mandible
- Young HORSE & CATTLE
Fibrous tissue (fibroblasts) w/ woven bone and osteoblasts
Chondroma/sarcoma
Tumors of hyaline cartilage
- NO osteoid
- *Mets to LUNGS
- *Bypass LN
Osteoma/sarcoma
Central = in medullary cavity Perio-steal = from periosteum onto medullary Paro-steal = from periosteum into soft tissue
- Rads = common to see starburst
MultiLobular Tumor of Bone
- Single Nodular Immobile mass
- partially mineralized
- separated by CT
- Flat bones (skull, hard palate)
- DOGS
