Inflammatory Myopathies - Polymyositis, Dermatomyositis Flashcards

1
Q

Polymyositis
-pathophysiology
-associations
-presentation
-investigation

A

Muscle fibre inflammation => symmetrical, proximal muscle weakness

Middle aged females
-idiopathic, connective tissue disorder, malignancy associations

Proximal muscle weakness, tenderness
Resp muscle weakness
ILDs
Raynaud’s
Dysphagia, dysphonia

High CK, LDH, aldolase
EMG
Muscle biopsy
Anti-synthetase

High dose CS tapered
Azathiopurine as steroid sparing

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2
Q

Dermatomyositis
-pathophysiology
-associations
-presentation
-investigations
-management

A

Muscle fibre inflammation => symmetrical, proximal muscle weakness and skin lesions

Can be idiopathic
-connective tissue disorders
-malignancy

Skin features
-photosensitive
-macular rash on back, shoulder
-heliotrope rash on eyes
-Gottron’s papules
-mechanics hands
-nailfold capillary dilation

Myositis features

Majority are ANA positive
Some will be Jo, SRP, Mi-2AB positive
CK high
Skin, muscle biopsy

Pred

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