Inflammatory Myopathies - Polymyositis, Dermatomyositis Flashcards
Polymyositis
-pathophysiology
-associations
-presentation
-investigation
Muscle fibre inflammation => symmetrical, proximal muscle weakness
Middle aged females
-idiopathic, connective tissue disorder, malignancy associations
Proximal muscle weakness, tenderness
Resp muscle weakness
ILDs
Raynaud’s
Dysphagia, dysphonia
High CK, LDH, aldolase
EMG
Muscle biopsy
Anti-synthetase
High dose CS tapered
Azathiopurine as steroid sparing
Dermatomyositis
-pathophysiology
-associations
-presentation
-investigations
-management
Muscle fibre inflammation => symmetrical, proximal muscle weakness and skin lesions
Can be idiopathic
-connective tissue disorders
-malignancy
Skin features
-photosensitive
-macular rash on back, shoulder
-heliotrope rash on eyes
-Gottron’s papules
-mechanics hands
-nailfold capillary dilation
Myositis features
Majority are ANA positive
Some will be Jo, SRP, Mi-2AB positive
CK high
Skin, muscle biopsy
Pred