Inflammatory Bowel diseases Flashcards
Inflammatory bowel disease includes
ulcerative colitis and crohn’s
differences of ulcerative colitis and crohn’s onset
C-gradual, UC- sudden or gradual
differences of ulcerative colitis and crohn’s distribution
C-mouth to anus, skip areas, UC- distal to proximal, no skip
differences of ulcerative colitis and crohn’s depth of lesion
C- trasmural, UC- mucosal
differences of ulcerative colitis and crohn’s symptoms
C- diarrhea/pain, UC- bloody, pus, diarrhea, tenesmus
differences of ulcerative colitis and crohn’s complications
C-fistulas, toxic megacolon, colon CA, UC: toxic megacolon and colon cancer
Ulcerative cholitis
chronic recurrent disease, starts at rectum and moves proximally, contained within colon, toxic megacolon and malignancy are more likely in UC than C, smoking is protective
Symptoms of UC
inflammatory diarrhea, tenesmus, pain in LLQ (rare), weight loss, malaise, fever
Diagnosis of UC
CBC: anemia, ESR: increased, Albumin: decreased, Xray will show colonic dilatation, diagnostic is colonoscopy (avoid in severe) or sigmoidoscopy
Treatment of UC
topical or oral aminosalicylates, corticosteroids, immunomodulators, surgery can be curative
Crohn’s disease
cause is unknown, genetic predispostion, involves: s/l colon, mouth, esophagus, stomach, but mostly terminal ileum and r colon, not usually rectum, has skip areas
Symptoms of Crohn’s
abdominal cramps, chronic diarrhea,
Diagnosis of crohn’s
anemia, increased ESR, electrolyte imbalances colonoscopy, biopsy, granuloma common
Treatment of Crohn’s
acute: oral corticosteroids, Maintenance: mesalamine, MTX, smoking cessation, B12, folate, Vit D, surgery is not curative
Toxic megacolon
Emergency, extreme dilatation and immobility of colon, Hirschsprung’s disease, ulcerative colitis, Crohn’s. and infectious causes
Symptoms of toxic megacolon
fever, prostration, severe cramps, abd distention
Diagnosis of Toxic megacolon
rigid abd, rebound tenderness, xray shows colon dilatation
Treatment of Toxic megacolon
Decompression of the colon, fluid and electrolyte balances
Ischemic bowel disease
Acute or chronic, >50 yo, intestinal infarction is more common in the small bowel than large, shock is common
Acute mesenteric ischemia
emergency, high mortality, arterial embolus/thrombus, venous thrombosis, sudden onset of severe abd pain
Chronic mesenteric ischemia
blood supply is present but insufficient, abd angina and pain 10-30 min after eating, relieved by squatting or lying down
Diagnosis of ischemic bowel
Ct to rule out other abd causes, diagnostic is colonoscopy
Treatment of ischemic bowel disease
surgery to revascularize intestine, hydration
Intussusception
invagination of proximal segment of bowel into portion distal to it, most common in children