Inflammatory Bowel Disease(IBD)

Question 1

what diseases are included in inflammatory bowel disease(IBD)

Answer 1

Crohn’s disease and Ulcerative colitis

Question 2

briefly describe what type of diseases IBDs are

Answer 2

chronic inflammatory and ulcerating conditions

Question 3

in what gender and age group are IBDs most common

Answer 3

men <40years

Question 4

what are some of the extraintestinal symptoms seen in IBD

Answer 4

anaemia, mouth ulcers, uveitis(eyes), enteropathic arthritis

Question 5

what investigations are done for IBDs

Answer 5

endoscopy + mucosal biopsy, plain abdominal x-ray

Question 6

what is investigated in IBDs in blood tests

Answer 6

C-reactive protein(CRP), albumin, pANCA antibody(in ulcerative colitis)

Question 7

what drugs are given to induce remission during flares of IBD

Answer 7

prednisolone or budesonide

Question 8

give an example of a 5-AS(5-aminosalicylate) drug used in IBD treatment

Answer 8

sulfasalazine

Question 9

what role to 5-AS(5-aminosalicylate) drugs play in IBD treatment

Answer 9

reduce risk of developing colon cancer

need to monitor renal function when given

Question 10

give an example of an immunosuppressant used in IBD treatment

Answer 10

azathioprine

Question 11

give an example of an anti-TNF drug used in IBD treatment

Answer 11

infliximab

Question 12

describe the effect/role of anti-TNF drugs in IBD treatment

Answer 12

patient often in full remission for 8-12 weeks after single infusion

Question 13

what emergency circumstances would permit surgery for IBD

Answer 13

fistulae, abscess, small bowel obstruction, failure to respond to medical therapy