Alcoholic liver disease & Non-alcoholic liver disease Flashcards
what different pathologies are seen in alcoholic liver disease
fatty liver, alcoholic hepatitis, alcoholic cirrhosis
at what stage does alcoholic liver disease go from reversible to irreversible
when it develops from hepatitis to fibrosis
describe the features of alcoholic hepatitis
hepatocyte necrosis, neutrophils, pericellular fibrosis
how is fatty liver in alcoholic liver disease managed
patient told to stop drinking, fat will disappear if they do and liver biochem usually returns to normal
describe the clinical features of fatty liver in alcoholic liver disease
often no symptoms or signs
what investigations are done for alcoholic liver disease
liver biopsy, LFTs, sereology
what drugs are often used for alcoholic cirrhosis
steroid therapy
describe what clinical features can be seen in alcoholic cirrhosis
hepatomegaly, jaundice, ascites, encephalopathy(degenaration of brain), can have very few symptoms
describe the order of pathology of both alcoholic liver disease and non-alcoholic fatty liver disease(NAFLD)
causes=> inflammation/hepatitis=>cirrhosis=>chronic liver failure
what is non-alcoholic fatty liver disease(NAFLD) called as fibrosis begins to occur
non-alcoholic steatohepatitis
who is more at risk of developing NAFLD/NASH
obese, diabetics, hyperlipidaemia, hypertension
what is the main management used for NAFLD/NASH
weight loss + exercise, healthy diet
